Table 3

Multivariable associations between explanatory variables, with and without adjustment for intermediary variables, and physical summary score

	Physical summary score
	Adjusted for other intrinsic, extrinsic, and disease related factors			Adjusted for all variables
Variable	βValue	95% CI	p Value	βValue	95% CI	p Value
*Relative to 20–39 year baseline group.
†p Value from heterogeneity test for age group.
CI, confidence interval.
Intrinsic factors
Age (years)
40–49*	−3.3	−11.4 to 4.9		−0.9	−9.0 to 7.2
50–59	5.0	13.3 to 3.3		−4.6	−12.8 to 3.5
60–69	0.1	−9.1 to 9.3		−0.3	−9.4 to 8.7
70+	−6.1	−16.1 to 3.8	0.39†	−7.7	−17.5 to 2.2	0.25†
Women	−2.6	−7.7 to 2.5	0.32	−3.2	−8.1 to 1.8	0.21
Self esteem	3.7	0.5 to 6.8	0.02	1.2	−1.9 to 4.4	0.44
Self deprecation	−5.2	−8.0 to −2.5	<0.001	−1.1	−4.0 to 1.9	0.48

Extrinsic factors
Single v cohabiting	−2.6	−7.7 to 2.6	0.32	−3.3	−8.4 to 1.9	0.22
Educational level
Further	−1.7	−7.2 to 3.7	0.53	−3.9	−9.3 to 1.5	0.16
Higher	3.2	−2.7 to 9.2	0.28	4.8	−1.1 to 10.7	0.11
Employment status
Retired	−7.7	−14.3 to −1.2	0.02	−5.6	−12.0 to 0.9	0.09
Other	−3.3	−10.0 to 3.5	0.34	−1.5	−7.9 to 4.9	0.64
Social support	2.0	−0.6 to 4.6	0.13	1.4	−1.2 to 4.0	0.30

Disease related factors
Disease duration (years)
6–10	2.5	−3.7 to 8.7	0.43	2.5	−3.3 to 8.4	0.39
11–16	8.0	1.1 to 14.9	0.02	7.0	0.2 to 13.7	0.04
17+	11.1	4.3 to 17.9	0.002	8.5	1.8 to 15.3	0.01
Response to botulinum toxin
No benefit	0.5	−5.6 to 6.7	0.86	1.9	−4.2 to 7.9	0.55
Global severity	−8.7	−11.4 to −5.9	<0.001	−6.1	−8.9 to −3.3	<0.001

Intermediary variables
Social participation				−0.0	−2.6 to 2.5	0.99
Stigma				−1.5	−4.6 to 1.6	0.34
Acceptance of illness				−2.0	−4.5 to 0.5	0.12
Anxiety
Mild				−7.4	−13.1 to −1.8	0.01
Moderate				−6.8	−14.0 to 0.4	0.07
Severe				−12.2	−22.4 to −2.0	0.02
Depression
Mild				−10.4	−17.7 to −3.2	0.005
Moderate				−13.9	−23.5 to −4.3	0.005
Severe				−19.1	−31.7 to −6.6	0.003