Genotype distribution of −800, −509, and +25 polymorphisms in a case–control population, and in relation to amyloid peptide (Aβ40, Abβ2, and total Abβ) in brains of patients with Alzheimer's disease
| −800 | −509 | +25 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GG | GA | AA | CC | CT | TT | GG | GC | CC | |
| Values are n (%) (patients) or mean (SD) (brains). | |||||||||
| AD, Alzheimer's disease; Aβ, amyloid β peptide. | |||||||||
| AD patients | 528 (83.7) | 98 (15.5) | 5 (0.8) | 298 (41.4) | 335 (46.5) | 87 (12.1) | 602 (87.8) | 97 (13.8) | 3 (0.4) |
| Controls | 550 (86.1) | 86 (13.4) | 3 (0.5) | 285 (42.0) | 307 (45.2) | 87 (12.8) | 577 (85.5) | 96 (14.2) | 2 (0.3) |
| AD brains (n) | 60 | 7 | 1 | 38 | 35 | 5 | 68 | 13 | – |
| Aβ40 | 4.5 (4.2) | 2.0 (1.8) | 3.9 | 3.2 (3.1) | 4.8 (4.8) | 5.3 (3.9) | 4.2 (4.1) | 2.9 (3.4) | – |
| Aβ42(43) | 10.7 (4.7) | 12.5 (5.5) | 4.2 | 9.7 (4.2) | 11.0 (5.0) | 12.2 (5.3) | 10.8 (4.7) | 9.0 (4.7) | – |
| Total Aβ | 15.2 (7.5) | 14.5 (6.5) | 8.1 | 12.9 (5.9) | 15.8 (8.2) | 17.5 (8.3) | 15.0 (7.3) | 11.9 (6.3) | – |