Summary of the phenotypic appearance and neuropathology findings from patients with the known PARK mutations
| Phenotype | Neuropathology | |
|---|---|---|
| PARK 1 | Onset typically in 30 s and 40s | Nigral degeneration |
| Rapid disease progression | Lewy bodies | |
| Tremor uncommon | ||
| Good response to L-dopa | ||
| Early cognitive impairment | ||
| PARK 2 | Early onset typically, 20s, 30s or 40s | Nigral degeneration |
| Slow disease progression | No Lewy bodies except in rare case reports | |
| Symmetrical involvement | ||
| Focal dystonia | ||
| Sleep benefit | ||
| PARK 3 | Onset in 50s | Nigral degeneration |
| Good response to L-dopa | Lewy bodies | |
| Cognitive impairment | ||
| PARK 4 | Early onset | Nigral degeneration |
| Early weight loss | Lewy bodies | |
| Rapid disease progression | ||
| Good response to L-dopa | ||
| Some individuals have postural tremor only | ||
| PARK 5 | Onset age 50 | Nigral degeneration |
| Initial tremor prior to bradykinesia | Lewy bodies | |
| Good response to L-dopa | ||
| PARK 6 | Early onset typically in 30s | Unknown |
| Benign course | ||
| Predominant rest tremor | ||
| Good, Persistent response to L-dopa | ||
| Early onset of drug induced dyskinesias | ||
| PARK 7 | Early onset typically in 30s | Unknown |
| Asymmetrical onset | ||
| Benign course | ||
| Good persistent response to L-dopa | ||
| Focal dystonia | ||
| PARK 8 | Onset in 40s and 50s | Nigral degeneration |
| Asymmetrical onset | No Lewy bodies | |
| Good response to L-dopa |