Brain regions where regional cerebral blood flow values during the memory task were significantly correlated with measures of hippocampal grey matter atrophy in subjects with Alzheimer’s disease (n = 9)
| Areas of correlation | x* | y* | z* | Zmax† | Size‡ |
|---|---|---|---|---|---|
| *Coordinates of the voxel of maximum statistical significance within each region, according to the atlas of Talairach and Tornoux.37 †Z scores for the voxel of maximum statistical significance in each region (all significant at the p<0.001 level, uncorrected for multiple comparisons). ‡Total number of contiguous voxels in each region that surpassed the initial statistical threshold of Z=2.33. §Regions where correlations remained significant at the p<0.05 level corrected for multiple comparisons, using the theory of Gaussian random fields.41 BA, Brodmann area, L, left; R, right. | |||||
| Direct | |||||
| R superior temporal gyrus (BA 22/38) | 66 | −8 | −34 | 4.24 | 907 |
| L middle temporal gyrus (BA 21) | −66 | −14 | −26 | 4.04 | 398 |
| R superior temporal gyrus (BA 22) | 64 | −16 | 0 | 3.94 | 420 |
| L hippocampus/parahippocampal gyrus | −26 | −34 | −14 | 3.76 | 82 |
| L posterior cingulate gyrus (BA 31) | −4 | −42 | 34 | 3.49 | 265 |
| R superior temporal gyrus (BA 22) | 44 | −32 | 4 | 3.39 | 321 |
| Inverse | |||||
| R inferior frontal gyrus/insula§ | 32 | −10 | 10 | 4.42 | 1152 |
| L inferior frontal gyrus/insula§ | −40 | 4 | 14 | 4.18 | 1179 |
| L inferior frontal gyrus (BA 10/46) | −46 | 26 | 8 | 3.52 | 170 |
| R inferior frontal gyrus (BA 10/46) | 40 | 26 | 14 | 3.27 | 166 |
| R and L cerebella§ | 22 | −58 | −32 | 3.78 | 1821 |