Results of striatal and midbrain PET imaging and 3D-MRI volumetry in seven healthy controls, 24 patients with PD, and nine subjects with MSA-P
| Controls (n=7) | PD (n=24) | MSA-P (n=9) | |
|---|---|---|---|
| Data are presented as mean (SD) (statistically significant differences in bold letters). *p<0.05 compared with controls; †p<0.001 compared with controls; ‡p<0.0001 compared with controls; §p<0.05 compared with PD; ¶p<0.001 compared with PD; ¶p<0.0001 compared with PD (ANOVA and post-hoc Scheffé test). | |||
| FDOPA influx constants (Ki) | |||
| Caudate nucleus | 0.0105 (0.0014) | 0.0085 (0.0018) | 0.0081 (0.0025) |
| Putamen anterior | 0.0119 (0.0012) | 0.0072 (0.0023)‡ | 0.0058 (0.0020)‡ |
| Putamen posterior | 0.0115 (0.0012) | 0.0044 (0.0017)‡ | 0.0034 (0.0011)‡ |
| Putamen whole | 0.0116 (0.0008) | 0.0061 (0.0021)‡ | 0.0049 (0.0016)‡ |
| Midbrain | 0.0033 (0.0006) | 0.0031 (0.0008) | 0.0027 (0.0013) |
| RACLO binding indices | |||
| Caudate nucleus | 1.54 (0.22) | 1.76 (0.38) | 1.31 (0.49)§ |
| Putamen anterior | 2.36 (0.29) | 2.71 (0.39) | 1.61 (0.62)*¶ |
| Putamen posterior | 2.03 (0.21) | 2.79 (0.54)* | 1.20 (0.87)*¶ |
| Putamen whole | 2.25 (0.21) | 2.76 (0.42)* | 1.45 (0.68)*¶ |
| FDG values (rCMRGlc) (μmol/100g/min) | |||
| Caudate nucleus | 30.9 (4.8) | 30.6 (3.5) | 27.2 (4.0) |
| Putamen anterior | 39.6 (4.0) | 38.2 (5.5) | 29.9 (4.3)*¶ |
| Putamen posterior | 38.2 (4.5) | 38.0 (5.6) | 27.4 (4.6)†¶ |
| Putamen whole | 38.9 (4.0) | 38.1 (5.5) | 28.9 (4.4)*¶ |
| Midbrain | 23.4 (2.2) | 23.1 (2.4) | 22.6 (2.2) |
| Normalised FDG values (nrCMRGlc) | |||
| Caudate nucleus | 1.01 (0.10) | 1.06 (0.07) | 0.97 (0.11) |
| Putamen anterior | 1.30 (0.06) | 1.32 (0.10) | 1.07 (0.16)†¶ |
| Putamen posterior | 1.26 (0.08) | 1.31 (0.11) | 0.97 (0.16)ঠ|
| Putamen whole | 1.28 (0.06) | 1.31 (0.10) | 1.03 (0.16)ঠ|
| Midbrain | 0.77 (0.09) | 0.80 (0.07) | 0.80 (0.05) |
| 3D-MRI volumetry: regional volumes (cm3) | |||
| Caudate nucleus | 3.39 (0.50) | 3.84 (0.64) | 2.72 (0.44)¶ |
| Putamen anterior | 2.58 (0.44) | 2.73 (0.40) | 1.41 (0.43)ঠ|
| Putamen posterior | 1.65 (0.23) | 1.70 (0.23) | 0.78 (0.26)ঠ|
| Putamen whole | 4.23 (0.60) | 4.43 (0.57) | 2.20 (0.64)ঠ|
| Midbrain | 7.77 (1.20) | 7.47 (1.15) | 7.05 (0.60) |
| Putaminal anterior-posterior gradient | |||
| FDOPA | −3.2 (6.6) | −49.8 (22.4)‡ | −46.8 (23.2)† |
| RACLO | −10.0 (10.2) | 1.9 (9.2) | −19.8 (15.3)¶ |
| FDG | −3.8 (7.5) | −0.5 (5.2) | −9.0 (5.6)§ |