Cardiovascular and cerebrovascular variables in controls and patients with familial dysautonomia in the supine position and during 180 seconds of head up tilt
| Controls | FD patients | |||
|---|---|---|---|---|
| Variable | At rest | During HUT | At rest | During HUT |
| Values are mean (SD). | ||||
| Bold numbers indicate significant differences between supine and head up tilt values (Wilcoxon: p<0.05). | ||||
| BPdia, diastolic blood pressure; BPmean, mean blood pressure; BPsys, systolic blood pressure; CBVF, cerebral blood flow velocity; CVR, cerebral vascular resistance, calculated as ratio of BPmean (adjusted to brain level ) to CBFVmean; HF, high frequency power of heart rate oscillations (0.04–0.15 Hz); HUT, head up tilt; LF, low frequency power of heart rate oscillations (0.04–0.15 Hz); RMSSD, root mean square of successive differences. | ||||
| Heart rate (beats/min) | 68.0 (9.9) | 84.4 (14.6) | 77.0 (9.1) | 78.4 (8.9) |
| BPsys (mm Hg) | 104.9 (8.2) | 105.2 (18.1) | 138.2 (22.8) | 119.0 (15.4) |
| BPmean (mm Hg) | 72.3 (7.6) | 77.0 (17.2) | 101.1 (19.3) | 84.5 (10.2) |
| BPdia (mm Hg) | 56.0 (8.1) | 62.9 (13.9) | 82.5 (18.1) | 67.2 (8.6) |
| CBVFsys (cm/s) | 95.5 (13.9) | 86.4 (10.9) | 94.6 (23.8) | 93.4 (24.3) |
| CBFVmean (cm/s) | 65.4 (8.9) | 58.6 (8.3) | 71.1 (18.4) | 54.5 (14.2) |
| CBFVdia (cm/s) | 46.1 (5.9) | 43.5 (6.6) | 54.0 (10.4) | 37.4 (9.4) |
| CVR (mm Hg.s.cm−1) | 1.14 (0.2) | 0.84 (0.2) | 1.46 (0.37) | 1.19 (0.33) |
| Respiratory frequency (cycles/min) | 20.3 (5.0) | 16.6 (5.8) | 22.6 (4.8) | 22.8 (6.4) |
| End tidal CO2 (mm Hg) | 39.6 (4.3) | 39.0 (3.8) | 41.0 (4.8) | 40.2 (3.4) |
| RMSSD | 73.3 (42.2) | 24.8 (15.0) | 28.7 (14.4) | 19.9 (4.4) |
| CV | 8.1 (2.9) | 6.4 (1.7) | 5.4 (2.3) | 4.8 (1.7) |
| SD | 0.072 (0.023) | 0.046 (0.05) | 0.042 (0.019) | 0.035 (0.009) |
| LF ([beats/min]2) | 7.1 (4.3) | 16.3 (11.1) | 4.4 (3.8) | 4.8 (6.0) |
| HF ([beats/min]2) | 13.1 (17.3) | 5.4 (7.3) | 2.4 (2.3) | 1.8 (1.3) |