Genotype and allele frequencies of the Asp905Tyr polymorphism of regulatory subunit 3 of protein phosphatase 1 (PPP1R3) resulting from the 2713-G/T base substitution in 202 patients with AD and 160 age matched controls for the total population and after stratification by apolipoprotein E ε4 allele. Results from logistic regression analysis are also presented
| Total | Apolipoprotein E ε4 non-carriers | Apolipoprotein E ε4 non-carriers | ||||
|---|---|---|---|---|---|---|
| PPP1R3 | AD (n=202) | Controls (n=160) | AD (n=85) | Controls (n=126) | AD (n=117) | Controls (n=34) |
| *p<0.05. Data are number (%) | ||||||
| Genotypes | ||||||
| GG | 154 (0.76) | 134 (0.84) | 61 (0.72) | 105 (0.83) | 93 (0.79) | 29 (0.85) |
| GT + | 45 (0.22) | 24 (0.15) | 23 (0.27) | 19 (0.15) | 22 (0.19) | 5 (0.15) |
| TT | 3 (0.02) | 2 (0.01) | 1 (0.01) | 2 (0.02) | 2 (0.02) | 0 (0.00) |
| OR 1.85, CI 1.03 to 3.30, p=0.04* | OR 1.95, CI 0.98 to 3.85, p=0.06 | OR 1.62, CI 0.55 to 4.77, p=0.38 | ||||
| Alleles | ||||||
| G | 353 (0.87) | 292 (0.91) | 145 (0.85) | 229 (0.91) | 208 (0.89) | 63 (0.93) |
| T | 51 (0.13) | 28 (0.09) | 25 (0.15) | 23 (0.09) | 26 (0.11) | 5 (0.07) |
| OR 1.68, CI 0.98 to 2.88, p=0.06 | OR 1.69, CI 0.91 to 3.14, p=0.10 | OR 1.66, CI 0.59 to 4.66, p=0.33 | ||||