Table 3

Results from voxel based morphometry: group comparison analyses

Analysis	Contrast	Region	Voxel cluster	SPM_{z}	Peak coordinates
Region, spatial extent (voxel cluster), significance extent (SPM_{z}), and Talairach coordinates of peak effect are indicated. All results are reported at p < 0.05 (corrected for multiple comparisons).
AG, angular gyrus; ATTG, anterior transverse temporal gyrus; CG, cingulate gyrus; CS, cingulate sulcus; CIS, circular insular sulcus; EC, entorhinal cortex; GMC, grey matter concentration; GP, globus pallidus; GR, gyrus rectus; IC, insular cortex; inf, infinite; IOG, inferior occipital gyrus; IOS, intraoccipital sulcus; IPS, intraparietal sulcus; LSSO, left sided seizure onset; MFG, middle frontal gyrus; MOG, middle occipital gyrus; MTG, middle temporal gyrus; OS, olfactory sulcus; PG, parahippocampal gyrus; PoCG, postcentral gyrus; POF, parieto-occipital fissure; RSSO, right sided seizure onset; SCG, subcallosal gyrus; SFG, superior frontal gyrus; SMG, supramarginal gyrus; SOG, superior occipital gyrus; STG, superior temporal gyrus; STS, superior temporal sulcus.
All patients – controls	GMC reduction	Bilateral SFG, MFG	10012	Inf	7.0	42.9	40.2
		Right thalamus	2778	7.55	9.9	−8.4	7.8
		Left AG, SMG, SOG	3623	7.13	−50.7	−63.8	31.6
		Right cerebellum	5071	7.02	22.9	−81.6	−32.1
		Left cerebellum	2228	6.89	−37.8	−71.5	−25.9
	GMC increase	Bilateral anterior CG, GR, OS, SCG	6041	Inf	−8.0	19.9	−10.2
		Right STG, IC	1140	Inf	40.7	−17.7	−3.3
		Left CG	1214	7.44	−9.9	26.4	21.7
		Right PG, EC	2562	7.23	29.8	−22.5	−19.9
		Left PG	2377	7.05	−25.8	−34.8	−13.4
		Right amygdala	2445	6.85	18.9	−7.6	−15.6
		Right SFG	1594	6.12	23.9	59.6	2.6
		Right cerebellum	1305	5.99	12.9	−65.3	−18.6
		Left IC	1568	5.87	−40.8	1.5	11.0
LSSO patients – controls	GMC reduction	Left hippocampus	1343	7.12	−28.8	−14.5	−16.1
		Bilateral SFG, MFG, CS	14286	7.01	12.9	57.1	31.2
		Left MOG, AG	2818	6.48	−50.7	−66.5	35.4
		Left MFG	637	6.09	−45.7	27.7	29.0
		Left AG	311	6.04	−26.8	−58.7	54.3
		Right AG	413	5.99	42.7	−60.0	48.9
		Right SFG	516	5.92	5.0	−12.9	54.8
		Right thalamus	716	5.74	15.9	−16.2	7.2
		Right IPS	1052	5.69	28.8	−48.6	62.1
		Right IOS	337	5.61	35.8	−76.7	26.7
		Left MFG	340	5.55	−40.8	42.2	26.4
		Left thalamus	268	5.54	−12.9	−12.3	8.9
		Left AG, SMG	939	5.44	−39.8	−36.7	45.9
		Left cerebellum	269	5.41	−40.8	−70.5	−24.3
	GMC increase	Bilateral anterior CG, GR, OS	3409	6.77	−8.0	19.9	0.2
		Left PG	1952	6.45	−25.8	−33.8	−12.8
		Right amygdala, GP	3785	6.06	15.9	0.1	−15.9
		Right IC, ATTG	1114	5.77	38.8	−18.7	−3.3
		Right cerebellum	3911	5.75	17.9	−58.4	−17.3
		Left cerebellum	3090	5.73	−12.9	68.6	−25.2
		Left IC	2045	5.59	−40.8	5.2	6.2
		Right PG, hippocampus	1189	5.44	29.8	−24.3	−18.1
RSSO patients – controls	GMC reduction	Right hippocampus	1492	7.33	34.8	−22.0	−9.8
		Right thalamus	1261	6.89	15.9	−16.2	7.2
		Bilateral SFG	2265	6.78	20.9	30.7	49.1
		Right cerebellum	9066	6.76	18.9	−80.0	−36.4
		Right PoCG	759	6.51	39.8	−26.7	51.8
		Right SFG	405	6.23	5.0	−12.8	56.7
		Precuneus, POF	3244	6.02	7.0	−69.4	36.4
		Left IOG	372	5.87	−14.9	−97.5	1.4
		Left SOG	846	5.71	−29.8	−75.5	31.2
		Left cerebellum	3181	5.59	−31.8	−77.3	−23.9
		Left thalamus	363	5.51	−13.9	−16.2	7.2
		Right MFG	432	5.49	36.8	8.5	52.9
		Left cerebellum	463	5.47	−38.8	−44.2	−25.5
	GMC increase	Bilateral anterior CG, GR, OS, SCG	5836	6.59	4.0	34.6	−10.1
		Right IC, STS, MTG	4301	6.52	43.7	−15.9	−6.8
		Right PG	2125	6.38	29.8	−21.6	−21.6
		Left CG	1177	6.27	−9.9	26.4	21.7
		Left amygdala, GP	1603	6.11	−24.8	−6.4	−10.6
		Bilateral posterior CG	1642	5.99	4.0	−33.8	26.4
		Right CIS	1274	5.73	31.8	17.9	−12.6
		Right SFG	1701	5.66	19.9	55.8	5.6