Regional grey matter density reduction in 29 mild to moderate AD patients compared with 26 non-demented controls
| Stereotactic coordinates (mm) | |||||
|---|---|---|---|---|---|
| Cluster size k (mm3) | Region | x | y | z | Z score |
| L=left, R=right. The first line denotes the presence of a 3D cluster made of 138 contiguous voxels of significantly decreased (p<0.05 corrected for multiple comparisons) grey matter density. The most significant voxel of the cluster has stereotactic coordinates of 32, −4, and −20 and is located in the region of the right hippocampal/amygdalar complex. Within the same cluster there is a second peak of significance distant more than 8 mm from the former and located at 26, −6, −14. | |||||
| 138 (1104) | R hippocampus (head)/ amygdala | 32 | −4 | −20 | 5.99 |
| R hippocampus (head)/ amygdala | 26 | −6 | −14 | 5.79 | |
| 45 (360) | R uncus | 20 | 6 | −22 | 5.92 |
| R anterior amygdala | 26 | 10 | −26 | 5.84 | |
| 45 (360) | R hippocampus (tail) | 24 | −34 | 4 | 5.60 |
| 43 (344) | R anterior cingulate | 8 | 34 | 18 | 5.58 |
| 12 (96) | L middle temporal gyrus | −56 | −14 | −14 | 5.26 |
| 56 (448) | L hippocampus (head) | −26 | −8 | −16 | 5.21 |
| 13 (104) | L hippocampus (body) | −36 | −28 | −12 | 5.20 |
| 5 (40) | L caudate (head) | −10 | 20 | 2 | 5.14 |
| 8 (64) | R superior temporal gyrus | 54 | −42 | 14 | 5.09 |
| 33 (264) | R middle temporal gyrus | 52 | −30 | −2 | 5.07 |
| R middle temporal gyrus | 54 | −22 | −10 | 4.84 | |
| 4 (32) | L precuneus | −10 | −62 | 34 | 5.03 |
| 9 (72) | R precuneus | 18 | −66 | 32 | 4.96 |
| 4 (32) | L middle frontal gyrus | −26 | −10 | 56 | 4.95 |
| 4 (32) | L middle frontal gyrus | −28 | 44 | −12 | 4.94 |
| 8 (64) | R fusiform gyrus | 52 | −40 | −22 | 4.89 |
| 3 (24) | L precuneus | −10 | −54 | 36 | 4.82 |
| 1 (8) | R hippocampus (body) | 38 | −24 | −14 | 4.80 |
| 1 (8) | L insula | −44 | 10 | −2 | 4.78 |
| 1 (8) | L anterior amygdala | −24 | 8 | −24 | 4.78 |
| 3 (24) | R uncus | 28 | −8 | −38 | 4.76 |
| 4 (32) | R middle temporal gyrus | 52 | −8 | −16 | 4.75 |
| 2 (16) | R insula | 44 | −26 | 18 | 4.75 |
| 4 (32) | R precuneus | 4 | −52 | 30 | 4.75 |
| 1 (8) | R fusiform gyrus | 58 | −36 | −26 | 4.75 |
| 2 (16) | R insula | 50 | −4 | 8 | 4.74 |
| 1 (8) | R hippocampus (tail) | 38 | −30 | −12 | 4.74 |
| 1 (8) | L posterior cingulate | 0 | −46 | 44 | 4.71 |
| 1 (8) | R insula | 38 | 4 | 12 | 4.71 |
| 1 (8) | R hippocampus (tail) | 36 | −32 | −10 | 4.70 |
| 1 (8) | R superior temporal gyrus | 54 | −58 | 28 | 4.69 |
| 1 (8) | L precuneus | −30 | −70 | 34 | 4.69 |