Muscle pathology in patients with anti-SRP antibodies
| Patient No | |||||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | |
| NA, tissue type not present for evaluation in biopsy; +, present in biopsy; −, not present in biopsy. | |||||||
| Time from disease onset to muscle biopsy (months) | 5 | 36 | 3 | 8 | 10 | 3 | 2 |
| Pathological features | |||||||
| Lymphocytic inflammation | |||||||
| Perimysial | − | − | − | − | − | − | − |
| Endomysial | ± | − | + | − | − | − | − |
| Perivascular | + | − | − | − | − | − | − |
| Muscle fibre size | |||||||
| Variation | + | NA | + | + | + | + | + |
| Bimodal | + | NA | + | + | + | + | + |
| Hypertrophy | + | NA | + | + | + | + | − |
| Hypercontracted fibres | + | NA | − | + | − | − | − |
| Grouped small round fibres | + | NA | + | + | + | + | + |
| Perifascicular atrophy | − | NA | − | − | − | − | − |
| Muscle fibre pathology | |||||||
| Necrosis | |||||||
| Scattered | + | NA | + | + | + | + | + |
| Regional (large groups) | − | NA | − | − | − | − | − |
| Regeneration | + | NA | + | + | + | + | + |
| Coarse internal architecture | + | NA | + | + | + | + | + |
| Immature (2C) fibres | + | NA | + | + | − | + | + |
| Mitochondrial changes | − | NA | − | − | − | − | − |
| C5b-9 deposition | ± | NA | − | − | − | − | − |
| Connective tissue features | |||||||
| Endomysial | |||||||
| Increased | + | NA | + | + | + | + | + |
| Acid phosphatase+/CD68+ cells | + | NA | + | + | + | + | + |
| Perimysial | |||||||
| Fragmentation | − | − | + | − | − | − | − |
| Alkaline phosphatase staining | + | − | + | − | + | − | − |
| Acid phosphatase+/CD68+ cells | − | − | + | − | − | + | − |
| Vessels | |||||||
| Capillaries | |||||||
| Reduced number | + | NA | + | − | + | − | + |
| Enlarged size | + | NA | + | + | + | + | + |
| C5b-9 deposition | + | + | + | + | + | + | + |