(A) Patients scanned up to six hours after stroke
|
Early signs |
Barber 200023 | 156 | 3 | multivariate | rt-PA | 75% | NIH<10 in 30%
NIH>20 in 21% | anterior circulation | mRS 3–6 at 3 months | yes ASPECTs score <8 |
Patel 200126 | 616 | 3 | multivariate | NINDS | 31% | median NIH 13 | all subtypes | mRS 2–6 at 3 months | yes marginal, but not with response to rt-PA |
v Kummer 200125 | 786 | 3 | none | ECASS2 | 57% | mean NIHSS 11,5 | hemispheric infarct | mRS 2–6 at 3 months | yes |
Buttner 199720 | 95 | 6 | univariate | unknown | 47% | mean SSS 32 | MCA Infarct | mRS 2–6 at 4 weeks | yes, but 25% with CT signs had benign course |
Censori 19933 | 172 | 6 | multivariate | unknown | 32.4% | 9.3% stuporous patients | anterior circulation | mRS 3–5 at 6 months | no |
Cornu 200024 | 1292 | 6 | multivariate | MAST I, ASK, MAST E | 27%
(5–64%) | 21% stuporous patients | all subtypes | mRS at 3 months | no |
Manelfe 199921 | 603 | 6 | multivariate | ECASS I | 86,50% | mean SSS 28 | hemispheric infarct | mRS 3–6 at 3 months | yes |
v Kummer 199710 | 620 | 6 | multivariate | ECASS I | 52% | mean SSS 27,5 | hemispheric infarct | mRS 2–6 at 3 months | yes |
Trouillas 199822 | 100 | 7 | multivariate | rt-PA | 87,60% | mean SSS 29.3 | anterior circulation | mRS 2–6 at 3 months | yes |
(B) Patients scanned up to two weeks after stroke
|
Established signs |
Moulin 19967 | 100 | 14 | none | anticoagulants, anitaggregants thrombolysis | 94% | mRS at discharge | MCA Infarct | mRS 5–6 at 14 days | yes |
Zorzon 199327 | 80 | 24 | multivariate | unknown | 17,5%
(HMCA) | unknown | unknown | mRS 4–6 at 1 months | yes (for HMCA) |
Candelise 19916 | 1048 | 48 | multivariate | Italian hemodilution trial | 50% | 50% severe strokes | all subtypes | death at 6 months | relation to death RR=2 |
Chamorro 199528 | 208 | 72 | multivariate | anticoagulants, anitaggregants | 41% | mean Matthew 78.4 | all subtypes | SOS 4–6 at 10 days | no (but infarct volume) |
Rasmussen 19922 | 210 | 72 | multivariate | unknown | 76% | 30% somnolent or comatose | all strokes | death at 3 weeks | yes |
Saver 199929 | 191 | 1 week | multivariate | RANTTAS | 69% | median NIH 10 | hemispheric infarct | BI <60 or
NIH >1 at 3 months | yes (correlation) |
Wardlaw 199819 | 993 | 2 weeks + | multivariate | antiaggregants | 60% | mRS, death and dependency at 6 months d | 13% TACI
40% PACI
26% LACI
16% POCI | mRS 3–6 at 6 months | yes (and death) |