Synergistic effects between unfavourable genotypes and clinical risk factors on the incidence of ischaemic stroke subtypes, as significant ORs (95% CI)
| Subtype of ischaemic stroke | |||
|---|---|---|---|
| Risk factors and genotypes | Large vessel | Small vessel | Mixed type |
| OR, odds ratio; CI, confidence interval; NS, not significant. | |||
| *p<0.0001 | |||
| Total number of cases | 350 | 239 | 278 |
| OR for hypertension+Leiden V | 7.3 (27.3 to 2.3)* | NS | 13(39.1 to 2.6)* |
| OR for hypertension + APOE 4 allele | 14.3 (61.3 to 3.1)* | 13.2 (58.3 to 2.9) * | 18(64.3 to 3.4)* |
| OR for diabetes mellitus + Leiden V | 12.3 (45.4 to 2.6)* | NS| | 10.3(35.4 to 2.8)* |
| OR for diabetes mellitus + APOE 4 allele | 17.3 (71.3 to 4.1)* | 19.3 (72.3 to 3.9)* | 18.4(71.3 to 3.8)* |
| OR for smoking + ACE D/D | NS | 11.6 (25.3 to 2.9)* | 13.2(28.3 to 2.8)* |
| OR for smoking + MTHFR 677TT | NS | 8.3 (19.6 to 2.1)* | 7.2(18.7 to 2.2)* |
| OR for smoking + APOE 4 allele | 16.8 (62.3 to 3.8)* | 17.3 (71.3 to 3.3)* | 14.2(58.3 to 4.0)* |
| OR for drinking + ACE D/D | NS | 14.2 (41.6 to 3.2)* | 13.2(44.3 to 3.1)* |
| OR for drinking + MTHFR 677TT | NS | 12.3 (33.4 to 3.1)* | 10.3(29.3 to 2.7)* |
| OR for drinking + APOE 4 allele | 12.6 (42.6 to 2.6)* | 11.2 (41.3 to 2.5)* | 8.6(29.3 to 2.2)* |