β Adrenoreceptor densities on peripheral blood mononuclear cells, magnetic resonance imaging findings, clinical status, and disability scores in five patients with primary progressive multiple sclerosis in a six month follow up study
| Months of follow up | ||||||
|---|---|---|---|---|---|---|
| Patient details | First | Second | Third | Fourth | Fifth | Sixth |
| Bold numbers indicate significantly increased values (above mean value of the controls plus 3 SD). E, enhanced MRI lesions; RM, remission. | ||||||
| Patient 1 (49 years; male) | ||||||
| β Adrenergic receptor sites/cell | 1200 | 1289 | 2489 | 1499 | 1490 | 1540 |
| MRI, brain | – | – | – | – | – | – |
| MRI, spinal cord | – | – | 1 E | – | – | – |
| Clinical status | RM | RM | RM | RM | RM | RM |
| Kurtzke score | 7.0 | 7.0 | 7.0 | 7.5 | 7.5 | 7.5 |
| Patient 2 (32 years; male) | ||||||
| β Adrenergic receptor sites/cell | 1020 | 1100 | 2300 | 1600 | 1279 | 1550 |
| MRI, brain | – | – | – | – | – | – |
| MRI, spinal cord | – | – | 1 E | – | – | – |
| Clinical status | RM | RM | RM | RM | RM | RM |
| Kurtzke score | 3.0 | 3.0 | 4.0 | 4.0 | 4.0 | 5.0 |
| Patient 3 (40 years; male) | ||||||
| β Adrenegic receptor sites/cell | 1400 | 1350 | 1200 | 1300 | 1500 | 1400 |
| MRI, brain | – | – | – | – | – | – |
| MRI, spinal cord | – | – | – | – | – | – |
| Clinical status | RM | RM | RM | RM | RM | RM |
| Kurtzke score | 6.5 | 6.5 | 6.5 | 6.5 | 6.5 | 6.5 |
| Patient 4 (46 years; male) | ||||||
| β Adrenergic receptor sites/cell | 1200 | 1500 | 1300 | 1280 | 1500 | 1400 |
| MRI, brain | – | – | – | – | – | – |
| MRI, spinal cord | – | – | – | – | – | – |
| Clinical status | RM | RM | RM | RM | RM | RM |
| Kurtzke score | 7.0 | 7.0 | 7.0 | 7.5 | 7.5 | 7.5 |
| Patient 5 (46 years; male) | ||||||
| β Adrenergic receptor sites/cell | 1600 | 1500 | 1400 | 1550 | 1600 | 1500 |
| MRI, brain | – | – | – | – | – | – |
| MRI, spinal cord | – | – | – | – | – | – |
| Clinical score | RM | RM | RM | RM | RM | RM |
| Kurtzke score | 5.0 | 5.0 | 5.0 | 5.0 | 6.0 | 6.0 |