Randomised controlled trials of surgery in Parkinson’s disease
| Trial group (main publication) | Intervention | Number of patients randomised | Maximum follow up reported (months) | Main outcome measures reported | Quality of life assessment | Economic assessment |
|---|---|---|---|---|---|---|
| UPDRS, Unified Parkinson’s Disease Rating Scale; CAPIT, Core Assessment Programme for Intracerebral Transplantation; PDQL, Parkinson’s Disease quality of life questionnaire; SIP, Sickness Impact Profile. | ||||||
| Atlanta Study Group Vitek, et al1 | Pallidotomy v medical treatment | 36 | 36 | UPDRS, CAPIT, Schwab and England | No | No |
| Netherlands (Amsterdam) Pallidotomy Study Group (NEPAS) De Bie, et al2 | Pallidotomy v delayed pallidotomy | 37 | 6 | UPDRS, Schwab and England, Dyskinesia Rating Scale, Barthel Index | Yes PDQL | No |
| Argentina Study Group Merello, et al3 | GP stimulation v Pallidotomy | 13 | 3 | UPDRS, CAPIT, Dyskinesia Rating Scale | No | No |
| Argentina Study Group Merello, et al4 | Bilateral pallidotomy v unilateral pallidotomy + GP stimulation | 6 | 3 | UPDRS, CAPIT | No | No |
| Amsterdam Study Group Schuurman, et al5 | Thalamic stimulation v thalamotomy | 45 | 6 | Dutch Frenchay Activities Index, UPDRS, Essential Tremor Rating Scale, Modified Tremor Scale | Yes Euroqol | No |
| Oregon Study Group Burchiel, et al6 | STN stimulation v GP stimulation | 10 | 30 | UPDRS, Hoehn and Yahr, Dyskinesia Rating Scale | No | No |
| San Fransisco Group Marks, et al7 | STN stimulation v GP stimulation | 49 | 6 | UPDRS | Yes SIP | No |