CSF hypocretin-1 in narcoleptic patients with cataplexy
| Subjects | Centre | Age | Sex | BMI | Age at onset of EDS | Age at onset of cataplexy | Family history | E | C | HH | SP | MSLT | SOREMP | REM latency | HLA DQB1*0602 | T | Hypo-1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Centre 1: Montpellier, France; Centre 2: Zurich, Switzerland | |||||||||||||||||
| F, female; M, male; BMI, body mass index; EDS, excessive daytime sleepiness; E, Epworth sleepiness scale; C, cataplexy severity scale; HH, hypnagogic hallucination; SP, sleep paralysis; Hypo-1, level of hypocretin-1 in the CSF (pg/ml); na, not available (adoptive child) | |||||||||||||||||
| Family history: 0, none; N, family history of narcolepsy; H, family history of hypersomnia | |||||||||||||||||
| T, treatment: Psychostimulant or anticataplectic treatment at time of CSF lumbar puncture | |||||||||||||||||
| *Status cataplecticus for several days when lumbar puncture was made | |||||||||||||||||
| †HLA DRB1*04/11 -DQB1*03 | |||||||||||||||||
| 1 | 1 | 36 | F | 23.8 | 28 | 28 | 0 | 18 | 3 | + | + | 4 | 3 | 61.5 | + | − | 85 |
| 2* | 1 | 55 | F | 31.6 | 46 | 46 | 0 | 24 | 5 | + | - | 3.6 | 2 | 17 | + | + | <10 |
| 3 | 1 | 57 | M | 21.5 | 51 | 53 | 0 | 23 | 3 | 0 | + | 4.6 | 5 | 63 | + | − | 46 |
| 4 | 1 | 52 | M | 25.9 | 15 | 15 | N | 21 | 5 | + | + | 4 | 5 | 129 | + | + | <10 |
| 5 | 1 | 33 | M | 26.8 | 16 | 20 | 0 | 23 | 4 | 0 | + | 2 | 4 | 6 | + | + | 79 |
| 6 | 1 | 39 | M | 27.5 | 18 | 27 | 0 | 14 | 5 | + | + | 4 | 4 | 2 | + | − | <10 |
| 7 | 1 | 19 | F | 27.7 | 4 | 17 | 0 | 12 | 3 | + | − | 1.7 | 4 | 3.5 | + | − | 51 |
| 8 | 1 | 20 | F | 26.4 | 10 | 13 | 0 | 24 | 1 | 0 | − | 2.25 | 3 | 68 | + | − | 38 |
| 9 | 1 | 22 | M | 22.6 | 12 | 20 | H | 17 | 4 | + | + | 6.4 | 3 | 95.5 | + | − | 126 |
| 10 | 1 | 17 | M | 17.2 | 7 | 9 | 0 | 18 | 5 | + | − | 0.8 | 5 | 0 | + | + | <10 |
| 11 | 1 | 55 | M | 26.1 | 40 | 50 | 0 | 24 | 4 | + | − | 6.1 | 4 | 3.5 | + | + | <10 |
| 12 | 1 | 35 | M | 29.8 | 20 | 19 | 0 | 18 | 5 | + | + | 1.5 | 4 | 7 | + | + | <10 |
| 13 | 1 | 55 | M | 26.8 | 20 | 24 | H | 18 | 3 | 0 | - | 6.5 | 4 | 0.5 | + | − | 25 |
| 14 | 1 | 13 | F | 13.7 | 4 | 4 | 0 | 18 | 5 | + | − | 2.6 | 4 | 40 | + | − | 14 |
| 15 | 1 | 29 | M | 24.8 | 29 | 29 | 0 | 23 | 5 | + | + | 3 | 5 | 0 | + | + | <10 |
| 16 | 1 | 23 | F | 23.4 | 20 | 20 | H | 24 | 5 | + | + | 1.2 | 5 | 0 | + | + | <10 |
| 17 | 1 | 26 | F | 32.6 | 1 | 12 | N | 24 | 5 | + | + | 1.6 | 5 | 69.5 | + | + | <10 |
| 18† | 1 | 51 | F | 21.8 | 25 | 47 | 0 | 14 | 5 | + | + | 14.6 | 2 | 22 | − | + | 271 |
| 19 | 1 | 26 | F | 21.4 | 11 | 11 | 0 | 19 | 5 | − | + | 2.6 | 3 | na | + | + | <10 |
| 20 | 2 | 64 | M | 26.3 | 43 | 44 | na | 19 | 5 | − | − | 4.5 | 4 | 5 | + | + | <10 |
| 21 | 2 | 34 | M | 25.8 | 25 | 23 | 0 | 18 | 3 | + | + | 4.9 | 4 | 6 | + | + | <10 |
| 22 | 2 | 21 | M | 20.2 | 12 | 14 | 0 | 16 | 4 | + | − | 5.3 | 5 | 15 | + | − | <10 |
| 23 | 2 | 52 | M | 28.1 | 24 | 24 | 0 | 20 | 4 | − | − | 4 | 3 | 28 | + | + | <10 |
| 24 | 2 | 29 | M | 27.5 | 17 | 18 | 0 | 16 | 4 | + | − | 6 | 4 | 7 | + | − | <10 |
| 25 | 2 | 18 | F | 18.0 | 14 | 12 | 0 | 17 | 4 | − | + | 2.5 | 4 | 8 | + | − | 14 |
| 26 | 2 | 37 | F | 22.8 | 20 | 20 | N | 17 | 3 | + | + | 4 | 3 | 10 | + | − | 145 |
| Mean (SD) | 35.3 (15.1) | 24.6 (4.4) | 20.5 (13) | 23.8 (13.5) | 19.2 (3.5) | 4.1 (1.03) | 4.0 (2.7) | 3.9 (0.9) | 26.7 (34.7) | 40.2 (60.2) | |||||||