Cedarbaum, 199114 | Early vs delayed initiation of L-dopa | Yes | No | None | NS | No | No | No |
Montastruc, 19949 | bromocriptine v levodopa | Yes | Yes, × 2 | None | NS | No | No | No |
Lees, 199513 | L-dopa+selegiline v L-dopa | NS | NS | None | NS | Yes | No | No* |
PSG, 19964 | Selegiline then L-dopa v L-dopa | Fluctuations: Yes | No | None | No | No | No | No |
| | Dyskinesias: No | No | None | No | No | No | No |
Dupont, 199610 | Madopar HBS v standard Madopar | Yes | NS | None | NS | Yes | Yes | Yes (UPDRS IV) |
Larsen, 19976 | L-dopa+selegiline v L-dopa | NS | Yes, × 1 | Motor fluctuations on qid L-dopa given q4h | NS | No | No | No |
Rinne, 19988 | Cabergoline v L-dopa | NS | Yes, × 1 | None | NS | Yes | No | No |
Koller, 199911 | Sinemet CR v regular Sinemet | Yes (patient diary) | Yes, × 1 | Dyskinesia >10% of waking day or “Off” greater than 20% of waking day by patient diary | NS | No | Yes | No |
| | Yes (examiner administered questionnaire) | Yes, × 1 | 5 of 10 questions on the examiner administered questionnaire answered affirmative | NS | No | Yes | No† |
Rascol, 200012 | Ropinirole v L-dopa | Yes | No | None | No | Yes | No | Yes (UPDRS IV) |
PSG, 20005 | Pramipexole v L-dopa | Yes | No | None | NS | No | No | No |
Caraceni, 20017 | L-dopa, lisuride, bromocriptine, selegiline | NS | NS | None | NS | No | No | No |