Ideal properties of viral vectors for gene therapy
| Reprinted by permission of Oxford University Press from ref 53. | ||
| (1) | Enough capacity of virus to package foreign gene | |
| (2) | Vector must be effectively delivered to target cells | |
| (i) | Appropriate route of delivery | |
| (ii) | No vector induced damage along route or at target | |
| (iii) | Vectors must remain intact during delivery | |
| (iv) | Vector must target appropriate neural cells | |
| (3) | No viral replication and/or reactivation at target tissue site | |
| (4) | Foreign gene must be stably expressed in target tissue | |
| (5) | Must have ability to control level of expression of the gene products | |
| (6) | Vector should not elicit immune responses in the host | |
| (7) | Appropriate in vitro and in vivo models should be available before human treatment | |