Early clinical data according to APOE genotype assessment
| APOE genotype | ||
|---|---|---|
| ε4 negative | ε4 positive | |
| Early clinical data for the 396 of 1133 patients who were successfully followed up for late assessment 15 to 25 years after injury, divided into APOE ε4 carriers and non-carriers. | ||
| Values are n or n (%). | ||
| *Pattern of injury from imaging and operative findings. | ||
| A&E, accident and emergency department; GCS, Glasgow coma score; GOS, Glasgow outcome scale; NART, national adult reading test. | ||
| Sample size | 279 | 117 |
| Year of injury | ||
| Median | 1980 | 1981 |
| Interquartile range | 1977 to 1984 | 1978 to 1985 |
| Age at injury (years) | ||
| Mean | 24.9 | 21.5 |
| SD | 15.6 | 14.2 |
| Male | 210 (75.3) | 81 (69.2) |
| Cause of injury | ||
| Road traffic accident | 181 (65.8) | 80 (68.4) |
| Fall under influence of alcohol | 20 (7.3) | 8 (6.8) |
| Other | 74 (26.9) | 29 (24.8) |
| Major extracranial complication | 101 (36.3) | 54 (46.2) |
| Lucid interval | 48 (17.8) | 21 (18.6) |
| GCS at A&E | ||
| 3–8 | 184 (82.9) | 88 (89.8) |
| 9–12 | 17 (7.7) | 4 (4.1) |
| 13–15 | 21 (9.5) | 6 (6.1) |
| Non-reacting pupils at A&E | 24 (10.4) | 15 (15.3) |
| Injury type* | ||
| Diffuse | 166 (59.5) | 67 (57.3) |
| Evacuated mass | 97 (34.8) | 43 (36.8) |
| Non-evacuated mass | 16 (5.7) | 7 (6.0) |
| GOS at six months | ||
| Vegetative/severe disability | 73 (26.2) | 28 (24.1) |
| Moderate disability | 86 (30.8) | 40 (34.5) |
| Good recovery | 120 (43.0) | 48 (41.4) |
| NART error score | ||
| 1–18 | 62 (22.2) | 24 (20.5) |
| 19–28 | 69 (24.7) | 27 (23.1) |
| 29–48 | 65 (23.3) | 26 (22.2) |
| Not completed | 83(29.7) | 40 (34.2) |