Ordinal logistic regression analyses assessing the relation between possession of one or more APOE ε4 alleles and function as assessed at late follow up
| Unadjusted analysis | Adjusted analysis* | |||||
|---|---|---|---|---|---|---|
| Outcome measure | Common odds ratio† | 95% CI | p Value | Common odds ratio† | 95% CI | p Value |
| Statistical analysis of the data presented in table 3 of the general assessment of functional outcome 15 to 25 years after a head injury for carriers and non-carriers of of APOE ε4. | ||||||
| *Adjusted for year of injury, age at injury, Glasgow coma score and pupil reaction at the accident and emergency department, type of injury, Glasgow outcome scale at six months, and national adult reading test. | ||||||
| †A common odds ratio of greater than 1 would indicate that possession of an APOE ε4 allele is associated with poor function. | ||||||
| ‡These results are based on 418 patients: the 396 who underwent neuropsychological assessment together with a further 22 where GOSE and APOE genotype were available. | ||||||
| CI, confidence interval; GOSE, extended Glasgow outcome scale; MMSE, mini-mental state examination. | ||||||
| MMSE, raw score | 0.94 | 0.64 to 1.39 | 0.772 | 1.18 | 0.72 to 1.95 | 0.507 |
| MMSE, centile score | 1.07 | 0.73 to 1.58 | 0.733 | 1.31 | 0.80 to 2.16 | 0.288 |
| Composite performance score | 0.97 | 0.66 to 1.44 | 0.896 | 1.07 | 0.62 to 1.83 | 0.807 |
| GOSE‡ | 1.19 | 0.82 to 1.72 | 0.356 | 1.36 | 0.84 to 2.19 | 0.212 |