Clinical and MRI characteristics of studied patients and healthy controls
| PP high T2LL | PP low T2LL | All PP | Controls | |
|---|---|---|---|---|
| PP, primary progressive; T2LL, T2 weighted lesion load; EDSS, Expanded Disability Status Scale; IBA, Index of Brain Atrophy; N/A, not applicable. | ||||
| Age, y | ||||
| Mean | 49.3 | 49.7 | 49.5 | 44.8 |
| SD | 9.1 | 6.2 | 7.5 | 9.9 |
| Range | 30.7–65.1 | 40.5–61.9 | 30.7–65.1 | 26.8–61.8 |
| n | 16 | 18 | 34 | 25 |
| n for MRSI | 10 | 14 | 24 | 19 |
| Disease duration, y | ||||
| Mean | 9.8 | 8.3 | 9.0 | N/A |
| SD | 9.0 | 6.2 | 7.5 | N/A |
| EDSS | ||||
| Mean | 4.9 | 4.7 | 4.8 | N/A |
| SD | 1.1 | 1.4 | 1.2 | N/A |
| T2 lesion load | ||||
| Mean | 9.49 | 1.17 | 5.09 | N/A |
| SD | 6.71 | 0.97 | 6.22 | N/A |
| IBA | ||||
| Mean | 0.685 | 0.729 | 0.708 | 0.761 |
| SD | 0.065 | 0.040 | 0.057 | 0.051 |
| p values | 0.0004 | 0.03 | 0.0004 | N/A |
| NAA:Cr | ||||
| Mean | 1.679 | 1.783 | 1.740 | 1.967 |
| SD | 0.124 | 0.165 | 0.156 | 0.131 |
| p values | 0.00001 | 0.001 | <0.00001 | N/A |