TMS results obtained in the healthy control group, family 189 and family 182
| Threshold (mA/μs) | CMCT (ms) | PMCT (ms) | M wave (mV) | S-R-C (110%) | S-R-C (120%) | S-R-C (130%) | S-R-C (140%) | SP (ms) | |
|---|---|---|---|---|---|---|---|---|---|
| “Threshold” indicates stimulus intensity which represents motor threshold; CMCT, central motor conduction time; PMCT, peripheral motor conduction time; M wave, amplitude of the muscle potential obtained by electrical stimulation of ulnar nerve (A) or peroneal nerve (B); S-R-C, stimulus-response-curve, MEP amplitudes are presented as percentage of M wave amplitude; SP, silent period. *p<0.05. | |||||||||
| A Recordings from right first dorsal interosseous muscle | |||||||||
| Control | 64.3 (4.7) | 6.3 (0.9) | 16 (1.6) | 16.6 (3) | 1.9 (1) | 4.8 (1.3) | 8.2 (2.8) | 12.9 (4) | 142 (20) |
| Fam 189 | 63.4 (13.8) | 7.2 (0.8) | 14.7 (1.8) | 17.6 (3.7) | 3.4 (2) | 8.5 (3.4) | 16.1 (8.1) | 23.7 (13.1) | 134.7 (27) |
| Fam 182 | 63.6 (7.6) | 5.6 (1.3) | 17 (1.1) | 19.5 (2.9) | 1.9 (1.1) | 5.4 (3.5) | 7.4 (5.8) | 12.7 (6.4) | 151.4 (30) |
| B Recordings from right tibial anterior muscle | |||||||||
| Control | 86.9 (10) | 11.1 (2) | 17.4 (2.1) | 7.4 (1.8) | 3.1 (1.3) | 4.7 (2.7) | 8.9 (6.9) | 12.5 (10.2) | 161.4 (37.6) |
| Fam 189 | 92.3 (17.2) | 13 (2.2) | 18.5 (1.8) | 7.7 (2.2) | 4.7 (4.1) | 11 (8.7) | 15.3 (10) | 14.4 (11.9) | 160.1 (9.6) |
| Fam 182 | 111.6 (26.5)* | 19.5 (3.4)* | 18.8 (1.9) | 7.9 (3) | 2 (1.8) | 7.3 (8.1) | 11.2 (10.4) | No data | 176.1 (47.5) |