Summary of the change in range of passive movement of the elbow, wrist, and fingers from cycle 1 baseline to week 4 of each treatment cycle (intention to treat population)
| Change from cycle 1 baseline to week 4 of each cycle | Cycle 1 n = 51 | Cycle 2 n = 46 | Cycle 3 n = 42 |
|---|---|---|---|
| Elbow | |||
| Mean (degrees [SD]) | 7.9 (14.4) | 7.9 (17.2) | 5.6 (24.9) |
| 95% CI | (3.8, 12.0) | (2.7, 13.1) | (−2.3, 13.6) |
| Wrist | |||
| Mean (degrees [SD]) | 31.2 (29.3) | 27.2 (31.0) | 28.9 (32.6) |
| 95% CI | (22.8, 39.7) | (17.9, 36.5) | (18.5, 39.3) |
| Fingers | |||
| Decrease ⩾1 (n [%]) | 0 (0%) | 1 (2%) | 0 (0%) |
| No change (n [%]) | 37 (74%) | 33 (73%) | 30 (75%) |
| Increase ⩾1 (n [%]) | 13 (26%) | 11 (24%) | 10 (24%) |