Patient | Sex | Age at time of SAH (years) | H&H1 | Severity of SAH2 | Aneurysm location | GOS3 | BDI4 | BMI (kg/m2) | Weight gain (kg) | Shunt | Max GH in ITT (μg/l) | Max GH in arginine test (μg/l) | Max. cortisol in ITT (μg/l) | Deficient hormone axis |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1According to the grading system of Hunt and Hess (1968), ranging from mild headache (grade 1) to coma (grade 5). | ||||||||||||||
2According to the classification of the severity of subarachnoid haemorrhage seen on cranial computed tomography by Fisher et al (1980), ranging from no blood present (grade 0) to severe, extended diffuse SAH (grade 3). | ||||||||||||||
3At six-month follow up, according to the Glasgow outcome scale (Jennett and Bond, 1967), ranging from no/minimal impairment (grade V) to death (grade I). | ||||||||||||||
4According to the Beck depression inventory (Beck 1961): mild depression is indicated by a score of ≥ 9, severe depression by a score of ≥ 21. Note that severe depression was an exclusion criterion from the present study. | ||||||||||||||
ACTH, adrenocorticotrophin; BDI, Beck depression inventory; BMI, body mass index; GH, growth hormone; GOS, Glasgow outcome scale; H&H, Hunt and Hess grading system; ITT, insulin tolerance test; MCA, middle cerebral artery; PcoA, posterior communicating artery; SAH, subarachnoid haemorrhage. | ||||||||||||||
1 | F | 38 | 3 | 3 | Middle cerebral | 4 | 11 | 20 | 0 | No | 24.4 | 13.6 | 464 | ACTH deficiency |
2 | F | 44 | 2 | 3 | Pericallosal | 4 | 4 | 25 | 10 | No | 18.7 | 33.2 | 466 | ACTH deficiency |
3 | F | 49 | 2 | 3 | Anterior communicating | 4 | 19 | 32 | 17 | No | 1.8 | 2.7 | 514 | Severe GH deficiency |
4 | F | 45 | 1 | 3 | Anterior communicating | 4 | 16 | 37 | 20 | Yes | <0.1 | 2.1 | 244 | Severe GH and ACTH deficiency |
5 | M | 38 | 2 | 2 | Anterior choroidal | 5 | 4 | 37 | 15 | No | 2.6 | 0.3 | 625 | Severe GH deficiency |
6 | F | 39 | 1 | 1 | Posterior communicating | 4 | 11 | 25 | 10 | No | 1.7 | 14.3 | 357 | ACTH deficiency |
7 | F | 45 | 5 | 3 | MCA (’01); PCoA (’95) | 3 | 11 | 25 | 0 | No | 3.3 | 1.4 | 536 | Partial GH deficiency |
8 | F | 46 | 3 | 2 | Anterior communicating | 4 | 11 | 26 | 15 | No | 13.9 | 16.2 | 368 | ACTH deficiency |
9 | F | 54 | 1 | 1 | Anterior communicating | 5 | 4 | 39 | 7 | No | 1.0 | 2.1 | 444 | Severe GH and ACTH deficiency |