Table 1

Characteristics of the patients with pituitary deficiency after subarachnoid haemorrhage

PatientSexAge at time of SAH (years)H&H1Severity of SAH2Aneurysm locationGOS3BDI4BMI (kg/m2)Weight gain (kg)ShuntMax GH in ITT (μg/l)Max GH in arginine test (μg/l)Max. cortisol in ITT (μg/l)Deficient hormone axis
1According to the grading system of Hunt and Hess (1968), ranging from mild headache (grade 1) to coma (grade 5).
2According to the classification of the severity of subarachnoid haemorrhage seen on cranial computed tomography by Fisher et al (1980), ranging from no blood present (grade 0) to severe, extended diffuse SAH (grade 3).
3At six-month follow up, according to the Glasgow outcome scale (Jennett and Bond, 1967), ranging from no/minimal impairment (grade V) to death (grade I).
4According to the Beck depression inventory (Beck 1961): mild depression is indicated by a score of ≥ 9, severe depression by a score of ≥ 21. Note that severe depression was an exclusion criterion from the present study.
ACTH, adrenocorticotrophin; BDI, Beck depression inventory; BMI, body mass index; GH, growth hormone; GOS, Glasgow outcome scale; H&H, Hunt and Hess grading system; ITT, insulin tolerance test; MCA, middle cerebral artery; PcoA, posterior communicating artery; SAH, subarachnoid haemorrhage.
1F3833Middle cerebral411200No24.413.6464ACTH deficiency
2F4423Pericallosal442510No18.733.2466ACTH deficiency
3F4923Anterior communicating4193217No1.82.7514Severe GH deficiency
4F4513Anterior communicating4163720Yes<0.12.1244Severe GH and ACTH deficiency
5M3822Anterior choroidal543715No2.60.3625Severe GH deficiency
6F3911Posterior communicating4112510No1.714.3357ACTH deficiency
7F4553MCA (’01); PCoA (’95)311250No3.31.4536Partial GH deficiency
8F4632Anterior communicating4112615No13.916.2368ACTH deficiency
9F5411Anterior communicating54397No1.02.1444Severe GH and ACTH deficiency