WISC scores for children aged 6 years or older by drug exposure
| AED regime | n | Mean maternal IQ (95% CI)* | Mean VIQ (95% CI) | Mean PIQ (95% CI) | Mean FSIQ (95% CI) |
|---|---|---|---|---|---|
| One way ANOVA for comparison of each monotherapy group, polytherapy group, and unexposed for: VIQ F = 3.32, df 5, p = 0.006; PIQ F = 1.110, df 5, p = 0.356; FSIQ F = 1.402, p = 0.224. 95% CI, 95% confidence intervals. | |||||
| Unexposed | 80 | 98.1 (95.6 to 100.7) | 90.9 (87.2 to 94.6) | 90.2 (86.1 to 93.0) | 89.5 (85.5 to 93.4) |
| Monotherapy | |||||
| Valproate | 41 | 98.3 (94.3 to 102.3) | 83.6 (78.2 to 89.0) | 94.0 (88.9 to 99.0) | 87.2 (81.9 to 92.5) |
| Carbamazepine | 52 | 101.6 (98.6 to 104.6) | 94.1 (89.6 to 98.5) | 89.4 (84.8 to 94.0) | 91.1 (86.4 to 95.8) |
| Phenytoin | 21 | 99.0 (94.5 to 103.4) | 98.5 (90.6 to 106.4) | 97.1 (91.7 to102.6) | 97.6 (90.3 to 105.0) |
| All | 120 | 99.5 (97.3 to 101.3) | 91.0 (87.9 to 94.1) | 92.3 (89.5 to 95.1) | 90.7 (87.7 to 93.8) |
| Polytherapy | |||||
| Including VPS | 28 | 97.4 (93.4 to 101.4) | 87.1 (81.6 to 92.7) | 89.1 (83.2 to 94.9) | 86.8 (81.2 to 92.4) |
| Excluding VPS | 21 | 98.3 (93.6 to 103.1) | 91.9 (85.6 to 98.2) | 89.1 (82.4 to 95.8) | 89.3 (83.5 to 95.2) |
| All | 49 | 97.8 (94.9 to 100.7) | 89.2 (85.1 to 93.2) | 89.2 (85.1 to 93.2) | 87.9 (83.9 to 91.8) |
| All valproate exposed | 69 | 97.9 (95.5 to 100.7) | 85.0 (81.2 to 88.9) | 92.0 (88.2 to 95.8) | 87.0 (83.2 to 90.8) |