Drug 1 | Drug 2 | Mean difference in VIQ (95% CI) | p |
---|---|---|---|
VPS monotherapy is associated with a significantly lower VIQ compared to carbamazepine, phenytoin, and unexposed. | |||
Valproate monotherapy | Carbamazepine monotherapy | −10.5 (−17.3 to −3.6) | 0.003 |
Valproate monotherapy | Phenytoin monotherapy | −14.9 (−24.1 to −5.6) | 0.002 |
Valproate monotherapy | Unexposed | −7.3 (−13.6 to −0.9) | 0.025 |
Polytherapy with VPS | Unexposed | −3.8 (−10.7 to 3.2) | 0.281 |
All valproate exposed | Unexposed | −5.9 (−11.2 to −0.6) | 0.030 |