Coagulation profile of patients with stroke/TIA with and without intracardiac thrombus
| Test (normal value) | Thrombus (n = 40) | No thrombus (n = 111) | p Value* |
|---|---|---|---|
| Values are mean (SD) or n (%). | |||
| *t Test or Fisher’s exact test. | |||
| ACA, anticardiolipin antibody; APC, activated protein C; aPTT, activated partial thromboplastin time; AT III, antithrombin III; dRVVT, diluted Russel viper venom test; PT, prothrombin time; TIA, transient ischaemic attack. | |||
| PT (11.5–13.5 s) | 12.4 (0.7) (n = 22) | 12.2 (0.7) (n = 87) | 0.2 |
| aPTT (20.0–31.6 s) | 26.7 (4.1) (n = 22) | 25.4 (4.8) (n = 87) | 0.2 |
| dRVVT (29.3–42.8 s) | 37.5 (15) (n = 17) | 34.2 (9.3) (n = 52) | 0.3 |
| Fibrinogen (150–400 mg/dl) | 499 (206) (n = 37) | 457 (142) (n = 85) | 0.2 |
| Protein C deficiency (70–180%) | 2/19 (10%) | 2/62 (3%) | 0.2 |
| Protein S deficiency (65–140%) | 0/19 (0) | 3/62 (5%) | 1.0 |
| AT III deficiency (80–120%) | 4/19 (21%) | 6/62 (10%) | 0.2 |
| APC resistance (>2.1) | 2/14 (14%) | 5/51 (10%) | 0.6 |
| ACA IgG (<10 gpl/ml) | 1/35 (3%) | 1/76 (1%) | 1.0 |
| ACA IgA (<10 sdu) | 1/35 (3%) | 3/76 (4%) | 1.0 |
| ACA IgM (<10 mpl/ml) | 2/35 (6%) | 1/76 (1%) | 0.2 |
| Hyperhomocysteinaemia (5.1–13.9 μmol/l) | 2/18 (11%) | 8/51 (16%) | 1.0 |