Demographic, clinical, and molecular biological data of the Huntington’s disease patients and controls
| HD patients | Normal database | HD patients: subgroup analyses | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Motor–severe | Motor–mild | p Value | Cognitive–severe | Cognitive–mild | p Value | CAG–high | CAG–low | p Value | |||
| Values are mean (SD). | |||||||||||
| Statistical significance of the differences between the groups calculated by F test. | |||||||||||
| CAG, cytosine-adenosine-guanosine; HD, Huntington’s disease. | |||||||||||
| n | 44 | 22 | 12 | 12 | 12 | 12 | 12 | 12 | |||
| Age (years) | 44.7 (10.7) | 44.1 (16.9) | 43.0 (10.8) | 44.3 (6.7) | NS | 47.4 (9.3) | 46.9 (9.2) | NS | 34.6 (5.5) | 54.5 (9.5) | 0.04 |
| Time from onset (years) | 5.1 (3.3) | 5.8 (2.4) | 3.2 (1.2) | 0.02 | 7.1 (4.2) | 4.3 (2.9) | NS | 5.6 (2.8) | 5.1 (2.9) | NS | |
| Motor score | 24.1 (12.1) | 39.4 (4.3) | 9.9 (3.1) | 0.01 | 35.6 (9.7) | 11.9 (5.1) | 0.02 | 22.0 (9.4) | 34.6 (8.4) | NS | |
| Cognitive score | 196.6 (63.1) | 142.8 (42.3) | 257.8 (48.4) | NS | 123.9 (21.9) | 271.5 (33.6) | 0.04 | 167.5 (45.0) | 209.7 (70.7) | NS | |
| CAG repeats | 45.5 (7.8) | 47.7 (4.0) | 43.1 (1.8) | NS | 45.0 (2.7) | 42.3 (2.3) | NS | 49.1 (3.1) | 40.7 (1.7) | 0.03 | |