SCA8 CTA/CTG repeat sizes among patients with ataxia and three control groups
| Subjects | N | No of patients heterozygous for each category of SCA8 CTA/CTG repeat size (%)* | Significance** | ||||
|---|---|---|---|---|---|---|---|
| 14–40 | 40–90 | 91–100 | >100 | >91 | |||
| *No patient was homozygous for the SCA8 expansion. | |||||||
| **All comparisons against ataxic group using a repeat size greater than 91 and Fisher’s exact test. | |||||||
| Ataxia | 173 | 167 (96.5%) | 0 | 1 (0.58%) | 5 (2.9%) | 6 (3.47%) | – |
| Anonymised healthy controls | 1190 | 1178 (99.0%) | 9 (0.76%) | 2 (0.17%) | 1 (0.08%) | 3 (0.25%) | p<0.0005 |
| ? Huntington’s disease | 137 | 132 (96.4%) | 3 (2.2%) | 2 (1.46%) | 0 | 2 (1.46%) | NS |
| Schizophrenia | 176 | 175 (99.4%) | 1 (0.6%) | 0 | 0 | 0 (0%) | p<0.05 |
| All controls | 1503 | 1485 (98.8%) | 13 (0.86%) | 4 (0.27%) | 1 (0.07%) | 5 (0.33%) | p<0.0005 |