Regime | n | Remission, 1 y | Remission, 2 y | Remission, 5 y |
---|---|---|---|---|
Mean daily dose of monotherapy: valproate 1286 mg, lamotrigine 324 mg, topiramate 256 mg. | ||||
y, year. | ||||
Monotherapy | ||||
Valproate (VPA) | 549 | 286 (52.1%) | 226 (41.2%) | 49 (8.9%) |
Lamotrigine (LTG) | 156 | 26 (16.7%) | 12 (7.7%) | 1 (0.6%) |
Topiramate (TPM | 26 | 9 (34.6%) | 3 (11.5%) | 0 (0%) |
Combination treatments | ||||
VPA/LTG | 157 | 24 (15.3%) | 13 (8.3%) | 2 (1.3%) |
VPA/TPM | 40 | 2 (5.0%) | 1 (2.5%) | 0 (0%) |
LTG/TPM | 21 | 3 (14.3%) | 2 (9.5%) | 1 (4.8%) |