Demographic and clinical characteristics at presentation for the tau mutation positive, familial tau mutation negative, and sporadic FTD patients
| Tau mutation positive* (n = 5) | Familial tau mutation negative (n = 9) | Sporadic (n = 18) | |
|---|---|---|---|
| *Mutations identified were all within or flanking exon 10: S305S,11 P301L (unpublished), 10+16 (unpublished), 10+19,12 and 10+29.12 | |||
| †Values are mean (SD), range. | |||
| ‡Non-significant differences between groups. | |||
| §Information not available for one case. | |||
| Demographic information | |||
| Sex (F/M) | 1/4 | 5/4 | 4/14 |
| Age of onset (years)†‡ | 50 (4.8), 43 to 55 | 57 (8.5), 44 to 71 | 52 (10), 33 to 73 |
| Symptom duration to diagnosis (years)†‡ | 1.4 (0.5), 1 to 2 | 3.7 (3.2), 1 to 10 | 4.1 (3.0), 1 to 10 |
| Deceased | 2 | 5 | 2 |
| Symptom presentations (n (%)) | |||
| Behaviour | 5 (100) | 8 (89) | 12 (67) |
| Apathy | 0§ (0) | 7 (78) | 10 (56) |
| Dysexecutive | 0 (0) | 7§ (87) | 6 (33) |
| Language | 1 (20) | 1 (11) | 8 (44) |
| Memory | 3 (60) | 7 (78) | 7 (39) |
| Apraxia | 1 (20) | 1 (11) | 0 (0) |
| Extrapyramidal | 1 (20) | 1 (11) | 3 (17) |
| Major psychiatric disorder | 0 (0) | 0 (0) | 6 (33) |