Demographic data, clinical features, and magnetic resonance imaging findings in the patients with vascular parkinsonism
| No | Sex | Age (years) | Duration (years) | Onset | Clinical features | MRI | Vascular risk factors | L-dopa response | MMSE | UPSIT |
|---|---|---|---|---|---|---|---|---|---|---|
| AF, atrial fibrillation; BG, basal ganglia; CHD, coronary heart disease; DWML, deep subcortical white matter lesions (bilaterally); GP, globus pallidus; HF, heart failure; LN, lentiform nucleus; MI, myocardial infarction; MMSE, mini-mental state examination; MRI, magnetic resonance imaging; PWML, periventricular white matter lesions (bilaterally); SN, substantia nigra; UPSIT, University of Pennsylvania smell identification test. | ||||||||||
| 1 | M | 66 | 7 | Acute | Hemiparkinsonism following stroke, later shuffling gait | Acute MRI: haemorrhagic infarct contralateral LN; later: DWML, PWML | Stroke | Equivocal | 30 | 23 |
| 2 | M | 67 | 3 | Acute | Hemiparkinsonism following stroke | Lesion contralateral SN | Hypertension, smoking, hyperlipidaemia, stroke | Not tried | 30 | 32 |
| 3 | M | 71 | 5 | Insidious | Shuffling gait, lower body parkinsonism | DWML, PWML | Hypertension, CHD, MI, hyperlipidaemia | Not tried (declined) | 28 | 31 |
| 4 | M | 75 | 6 | Insidious | Predominantly lower body parkinsonism | DWML, PWML | Hypertension, mitral valve prolapse, CHD | Good | 27 | 24 |
| 5 | M | 76 | 9 | Insidious | Shuffling gait, later bradykinesia including upper limbs, blepharospasm | DWML, PWML | Hypertension | Poor | 29 | 23 |
| 6 | M | 82 | 4 | Acute | Shuffling gait, predominantly lower body parkinsonism following stroke | Bilateral GP lesions, DWML, PWML | Stroke | Poor | 27 | 18 |
| 7 | M | 88 | 28 | Acute | Hemiparkinsonism with tremor, slowly progressive tremor dominant parkinsonism | Bilateral GP lesions, DWML, PWML | Hypertension, two strokes | Absent | 29 | 25 |
| 8 | M | 82 | 5 | Insidious | Asymmetric tremor dominant parkinsonism | Bilateral PWML, bilateral midbrain lesions | Hypertension, diabetes, CHD, HF | Good | 27 | 33 |
| 9 | F | 65 | 3 | Insidious | Shuffling gait, start hesitation. Mild central hemiparesis resulting from stroke | Bilateral lesions inferior BG, DWML, PWML | Hypertension, stroke | Not tried | 28 | 32 |
| 10 | F | 67 | 3 | Acute | Asymmetric parkinsonism with tremor, later predominantly lower body parkinsonism | Lesion contralateral GP, DWML, PWML | Hypertension, family history of stroke | Moderate | 30 | 29 |
| 11 | F | 68 | 4 | Acute | Hemiparesis resulting from stroke, later shuffling gait, bradykinesia | Lesion contralateral LN, DWML, PWML | Hypertension, stroke | Equivocal | 30 | 19 |
| 12 | F | 75 | 9 | Insidious | Shuffling gait, later asymmetrical parkinsonism with rest tremor | DWML, PWML | Hypertension, hyperlipidaemia, stroke | Equivocal (poor tolerability on low doses) | 27 | 21 |
| 13 | F | 76 | 4 | Insidious | Tremor, gait ignition failure | DWML, PWML | CHD, AF | Moderate | 29 | 25 |
| 14 | F | 79 | 3 | Acute | Hemiparkinsonism <1 month after stroke, later shuffling gait | Lesion contralateral LN, DWML, PWML | Hypertension, stroke, hyperuricaemia, CHD, family history of stroke | Moderate | 28 | 30 |