Cognitive performance and EEG frequency spectrum before and under rivastigmine treatment
| Before treatment | Under treatment | t Value | p Value | |
|---|---|---|---|---|
| MMSE, SIDAM, and SISCO scores and EEG spectral frequency powers are given as means (SD). Values of t and p were calculated using paired one sided Student t tests. Significant values in bold. | ||||
| Reassessment of MMSE, SIDAM, and SISCO was undertaken after six months of rivastigmine treatment. The second EEG recording was obtained after one week. | ||||
| MMSE, mini-mental state examination; SIDAM, structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia, and dementias of other aetiology; SISCO, SIDAM score. | ||||
| Cognitive performance | ||||
| MMSE | 20.2 (4.6) | 21.7 (4.9) | −1.607 | 0.063 |
| SISCO | 34.0 (8.4) | 35.4 (8.4) | −1.006 | 0.163 |
| SIDAM | ||||
| Orientation | 6.5 (2.5) | 7.3 (2.2) | −1.824 | 0.042 |
| Recall | 4.2 (0.9) | 4.4 (0.7) | −1.258 | 0.107 |
| Short term memory | 1.4 (1.6) | 2.0 (2.5) | −2.221 | 0.020 |
| Long term memory | 4.4 (1.7) | 4.1 (1.6) | 1.165 | 0.129 |
| Memory | 10.0 (2.9) | 10.5 (3.2) | −0.930 | 0.182 |
| Intellectual capabilities | 3.9 (1.3) | 3.7 (1.4) | 0.719 | 0.241 |
| Verbal and calculation capabilities | 4.1 (2.2) | 4.3 (2.1) | −0.507 | 0.309 |
| Visuospatial capabilities | 1.2 (1.2) | 1.3 (1.0) | −0.271 | 0.395 |
| Aphasia and apraxia | 8.3 (1.6) | 8.3 (2.0) | 0.000 | 0.500 |
| Higher cortical functions | 13.6 (3.8) | 13.9 (3.5) | −0.216 | 0.415 |
| EEG frequency spectrum | ||||
| Delta power (µV2) | 27.6 (26.4) | 26.7 (29.7) | 0.165 | 0.435 |
| Theta power (µV2) | 54.9 (65.3) | 44.4 (57.7) | 2.138 | 0.023 |
| Alpha power (µV2) | 50.6 (49.2) | 40.6 (45.2) | 1.489 | 0.076 |
| Beta power (µV2) | 27.7 (27.4) | 22.3 (22.0) | 1.239 | 0.116 |