Measures of dyskinesias and parkinsonism on 25 mg quetiapine and placebo
| Measures | Baseline mean (SD) | Placebo mean (SD) | % change | Quetiapine mean (SD) | % change | p Value for difference drug/placebo (two tailed) |
|---|---|---|---|---|---|---|
| AIM, Abnormal Involuntary Movement Scale; UPDRS, Unified Parkinson’s disease rating scale. | ||||||
| Per cent changes are the mean of person specific percentage changes, calculated in relation to person specific baseline measurements. | ||||||
| Video ratings | ||||||
| AIMS score | 8.36 (2.83) | 8.41 (2.92) | +1.0 | 8.02 (3.2) | −2.9 | 0.21 |
| Goetz score | 1.57 (0.5) | 1.52 (0.47) | −8.0 | 1.49 (0.52) | −5.3 | 0.85 |
| Lang & Fahn scale (score) | 14 | 13.5 | 13.5 | 0.92 | ||
| UPDRS item 32 (score) | 1.6 | 1.8 | 1.5 | 0.48 | ||
| UPDRS item 33 (score) | 1.9 | 1.6 | 1.9 | 0.16 | ||
| VAS three days | ||||||
| Severity (cm/day) | 37.2 | 22.7 | −36.6 | 22.4 | −38.8 | 0.89 |
| Duration (% of waking day) | 63.2 | 60.7 | −4.2 | 49.4 | −10.1 | 0.67 |
| L-dopa challenges | ||||||
| UPDRS part 3 “off” | 37.8 (5.47) | 38.1 (6.15) | +0.8 | 33.8 (8.97) | −10.6 | 0.17 |
| UPDRS part 3 “on” | 18.1 (10.64) | 14.9 (6.62) | −17.7 | 15.6 (5.78) | −13.8 | 0.50 |
| Diary 3 days | ||||||
| Off duration (hours/day) | 3.3 (1.89) | 3.3 (1.83) | 2.7 (1.83) | 0.44 | ||