Cognitive efficiency, memory, mood, and behavioural scores (mean (SD)) before, one year, and three years after STN DBS
| Before surgery | One year after surgery | Three years after surgery | Analysis of variance p = | ||
|---|---|---|---|---|---|
| Mattis DRS | (n = 66) | ||||
| total score | 136.8 (4.9) | 135.9 (6.9) | 134.6 (11.2) | 0.072 | |
| attention | 35.8 (0.9) | 35.9 (1.1) | 35.5 (1.3) | 0.017 | |
| initiation | 34.0 (3.6) | 32.6 (4.7) | 32.5 (5.3) | 0.036 | |
| construction | 6.0 (0.2) | 5.9 (0.2) | 5.8 (0.8) | 0.207 | |
| conceptualisation | 37.2 (2.2) | 37.1 (2.1) | 36.8 (3.1) | 0.442 | |
| memory | 23.9 (1.2) | 24.1 (1.5) | 23.7 (2.9) | 0.443 | |
| Wisconsin CST | (n = 69) | ||||
| number of categories | 5.1 (1.2) | 5.0 (1.4) | 5.0 (1.6) | 0.384 | |
| total errors | 7.3 (5.3) | 7.5 (6.1) | 7.2 (6.2) | 0.752 | |
| perseverative errors | 2.2 (2.0) | 2.4 (2.9) | 0.373 | ||
| maintaining errors | 1.1 (1.4) | 1.3 (1.8) | 1.3 (2.0) | 0.909 | |
| Lexical fluency | (n = 69) | ||||
| category | 14.4 (3.8) | 12.6 (3.7) | 12.7 (3.9) | <0.001 | |
| literal | 11.9 (4.3) | 11.1 (4.9) | 10.8 (5.2) | 0.149 | |
| total | 26.2 (7.0) | 23.7 (7.3) | 23.5 (7.8) | 0.001 | |
| Series | (n = 69) | ||||
| graphic | 7.8 (2.4) | 7.8 (2.6) | 7.7 (2.9) | 0.816 | |
| motor | 8.6 (2.2) | 8.6 (2.4) | 8.0 (3.1) | 0.138 | |
| Frontal score | (n = 69) | ||||
| 41.0 (7.5) | 39.6 (9.0) | 38.8 (10.5) | 0.042 | ||
| Grober and Buschke verbal learning test | (n = 51) | ||||
| free recall | 28.7 (6.1) | 28.5 (7.3) | 27.8 (8.4) | 0.479 | |
| total recall | 46.0 (2.8) | 46.2 (2.3) | 45.7 (3.7) | 0.384 | |
| delayed free recall | 10.9 (2.6) | 10.1 (2.9) | 10.5 (3.1) | 0.391 | |
| delayed total recall | 15.7 (0.7) | 15.7 (0.8) | 15.5 (1.3) | 0.168 | |
| recognition | 15.7 (0.9) | 15.6 (1.0) | 15.5 (1.1) | 0.150 | |
| Beck depression inventory | (n = 60) | ||||
| global score | 15.4 (7.2) | 11.5 (7.4) | 12.6 (8.6) | 0.001 | |
| categories of depression: | |||||
| absence (0–9) | n = 12 | n = 27 | n = 28 | ||
| mild (10–17) | n = 28 | n = 21 | n = 23 | ||
| moderate (18–24) | n = 14 | n = 10 | n = 3 | ||
| severe (25–59) | n = 6 | n = 2 | n = 6 | ||
| UPDRS I | (n = 69) | ||||
| item 2 (thought disorders) | 0.1 (0.4) | 0.3 (0.6) | 0.4 (0.7) | <0.001 | |
| item 4 (apathy) | 0.5 (0.8) | 0.9 (0.8) | 0.9 (1.1) | 0.005 |