Table 1

Genetic changes in cases with same lower grade, glioblastoma, and higher grade recurrences

Case*	Age†/Sex	Histology‡ P/R/RR	Treatment§	Interval¶ (months)	Loss of heterozygosity (LOH)††					LOH TP53	MUT** TP53	LOH 22q13	EGFR Ampl
Case*	Age†/Sex	Histology‡ P/R/RR	Treatment§	Interval¶ (months)	1p36	19q13	10p15	PTEN	DMBT1	LOH TP53	MUT** TP53	LOH 22q13	EGFR Ampl
*Number in parentheses denotes case number in a previous communication³
†Age (years) at first operation
‡P, primary tumour; R, first recurrence; RR, second recurrence; PA, pilocytic astrocytoma; DA, diffuse astrocytoma; AA, anaplastic astrocytoma; GBM, glioblastoma multiforme; GBM-PNET, primitive neuroectodermal tumour-like glioblastoma; GBM-glios, mixed glioblastoma-gliosarcoma; GBM-O, glioblastoma with oligodendroglial features; (A)O, (anaplastic) oligodendroglioma; (A)OA, (anaplastic) oligoastrocytoma
§RT, radiotherapy; BR, brachytherapy; CT, chemotherapy
¶Interval between operations
** Type and position of TP53 mutation were reported previously³ or can be obtained from the corresponding author (T.H.)
††A y denotes presence and n absence of the genetic change. Cases with additional genetic changes are shown in bold.
‡‡See table 2 for details. Imb denotes imbalance.
Same lower-grade recurrences
2020	27/M	DA/DA	−	17	n	n	n	n	n	n	n	n	n
2228	52/M	DA/DA	−	29	n	n	n	n	y	y	n	n	n
2509	39/F	DA/DA	RT	143	y	y	n	n	n	y	n/y	n	n
1112	22/F	OA/OA	−	14	y	y	n	n	n	n	n	n	n
305 (8)	38/M	AO/AO/AO	RT/−	26/15	y	y	n	n	n	n	n	n	n
347 (9)	28/F	AO/AO	−	53	y	y	n	n	n	n	n	y	n
814	62/M	AO/AO	RT	27	y	y	y	n	n	y	n	y	n
2250	47/M	AO/AO	−	9	y	y	n	n	n	n	n	n	n
2729	35/M	AO/AO	RT, CT	6	n	y	y	y	n	n	n	n/y	n/y
831 (10)	26/M	AA/AA	RT	36	n	n	n/y	n	n	y	n/y	n/y	n
1113	52/V	AA/AO	RT	92	n	y	n	y	y	y	y	n	n
1568	27/M	AA/(A)OA	RT	56	y	y	n	n	n	n	n	n	n
2404 (11)	31/F	AA/AA/AOA	RT/CT	5/53	y	y	n/n/y	n/n/y	n/n/y	y	y	n	n
2848	29/M	AOA/AO	CT	14	y	y	n	n	y	y	n	n	n
Glioblastoma recurrences
663 (13)	36/F	GBM/GBM		6	n	y	n	n	n	y	y	n	n
871 (19)	51/F	GBM-glios/GBM-glios	RT,BR	11	n	n	y	y	n/y	n	y	n	n
1143 (15)	42/M	GBM/GBM	RT/BR	9	n	n	n	n	n	n	n	n	y
1959 (12)	39/F	GBM/GBM	RT	45	n	n	n	n	n	n	n	n	n
1857 (14)	35/M	GBM/GBM	RT	40	n	n	n	n	n	n	y	n	n
1892 (17)	63/M	GBM/GBM	RT	8	n/y	n	n	n/y	n/y	n	n	n	n
2176 (18)	60/F	GBM/GBM	RT,BR	22	n	n	n	n	n	n	n	n	n
2403	26/M	GBM/GBM	RT	20	n	n	n	n	n	n	n	n	n
2406	45/F	GBM-O/GBM	RT	36	y	n/y	y	y	y	n	y	n/y	n
2516	41/M	GBM-glios/GBM-glios	BR	11	n	n/y	y	y	y	y	y	n	n
2656	57/M	GBM/GBM/GBM	RT, CT/−	3/22	n	n/n/y	y	y	y	n/n/y	n	n	n
2884	55/M	GBM/GBM-O	RT	6	n/y	y	y	y	y	n/y	n	y	n
Higher grade recurrences
2308 (1)	35/F	PA/GBM	−	12	n	n/y	n	n/y	n/y	n/y	y	n/y	n
2696	17/M	DA/DA/AA	−/−	62/27	n	n	n/n/y	n/n/y	n/n/y	n/n/y	y	n/n/y	n
1415 (2)	26/M	DA/AA	−	16	n	y	n	n	y	n	y	n	n
1454	29/M	DA/AA	−	88	n	n	n	n	n	y	y	n	n
1748 (3)	21/M	DA/AA	−	11	n	n	n	n	n	y	y	n	n
2540	40/F	DA/AA	−	37	n	n	n	n	n	y	y	n	n
2537	43/M	DA/AOA	−	33	n/y	n/y	n	n	n/y	n	y	n	n
1261 (5)	23/F	DA/GBM	−	58	n	n	n	n	n	y	y	n	n
912 (4)	50/M	DA/GBM-PNET	−	12	n	n/y	n	n	n	n/y	y	n/y	n
1083	45/F	O/AO	RT	25	n/y	n	imb/y‡‡	n	n/y	y	y	imb/y‡‡	n
2778	26/M	OA/O/AO	−/RT	11/40	y	y	n	n	n	n	y/n/n	n	n
1140 (6)	31/M	AA/AA/AAless diff	RT/−	37/14	n	n/n/y	n/y/y	n	n/n/y	n	y	n	n
2111	21/F	AA/GBM	RT	56	n	n	y/y‡‡	n	n	n	n/y	n	n
1866 (7)	36/M	AA/GBM/GBM	RT/−	8/9	n	n	n/n/y	n/n/y	n/n/y	y	y	n	n