Odds ratios for independent associations between test variables and dementia generated from logistic regression models used to predict probabilities of dementia caseness
| Tests+ | Model 1 | Model 2 | Model 3 | |
|---|---|---|---|---|
| FH+Age† | FH+Age+Cognitive tests† | FH+Age+Cognitive tests+APOE genotype† | ||
| †With 95% confidence intervals. | ||||
| FH, family history; NART, new adult reading test; PALT, paired associate learning test; RPM, Raven’s progressive matrices; TMT-A, trail making test A. | ||||
| FH | <0.78 | 1 | ||
| Loading | 0.79 to 0.89 | 1.40 (0.57 to 3.46) | 1.43 (0.56 to 3.68) | 1.34 (0.51 to 3.49) |
| 0.90 to 1.00 | 2.12 (0.90 to 4.97) | 2.31 (0.94 to 5.65) | 2.18 (0.88 to 5.43) | |
| Age (years) | 65.0 to 68.9 | 1 | ||
| 69.0 to 71.8 | 1.44 (0.64 to 3.23) | 1.60 (0.68 to 3.75) | 1.71 (0.72 to 4.04) | |
| 71.9 to 75.0 | 1.10 (0.47 to 2.62) | 0.99 (0.40 to 2.45) | 1.13 (0.45 to 2.83) | |
| TMT-A | <40 s | 1 | ||
| 40 to 56 s | 3.30 (1.00 to 10.8) | 3.49 (1.05 to 11.6) | ||
| >56 s | 4.78 (1.48 to 15.4) | 4.93 (1.51 to 16.8) | ||
| PALT | <17 | 1 | ||
| 17 or 17.5 | 1.16 (0.46 to 2.92) | 1.15 (0.45 to 2.94) | ||
| 18 | 1.24 (0.47 to 3.24) | 1.24 (0.47 to 3.30) | ||
| RPM | <14 | 1 | ||
| 14 to 17 | 0.39 (0.17 to 0.90) | 0.41 (0.17 to 0.97) | ||
| 18 to 24 | 0.40 (0.15 to 1.04) | 0.42 (0.16 to 1.11) | ||
| NART | <27 | 1 | ||
| 27 to 37 | 0.74 (0.31 to 1.78) | 0.69 (0.28 to 1.70) | ||
| 38 to 50 | 0.75 (0.28 to 2.00) | 0.70 (0.26 to 1.90) | ||
| APOE | 2/2 or 2/3 | 1 | ||
| 3/3 | 1.66 (0.36 to 7.78) | |||
| 4/* | 4.00 (0.84 to 19.0) | |||
| Step χ2 | 4.0 (4 df) | 21.3 (8 df) | 6.8 (2 df) | |
| p = 0.40 | p = 0.006 | p = 0.03 | ||
| Model χ2 | 4.0 (4 df) | 25.3 (12 df) | 32.2 (14 df) | |
| p = 0.40 | p = 0.01 | 0.004 | ||