Diagnostic accuracy of anosmia and other clinical criteria for the detection and discrimination of Lewy body variant cases
| Sensitivity* | Specificity† | PPV | NPV | Discrimination (LBV vAD) | |
|---|---|---|---|---|---|
| All values given are percentages with exact proportions in parentheses. | |||||
| *Sensitivity to LBV cases. | |||||
| †Specificity for non-LBV cases. | |||||
| AD, Alzheimer’s disease; DLB, dementia with Lewy bodies; LBV, Lewy body variant; NPV, negative predictive value (absence of Lewy bodies); PPV, positive predictive value (presence of Lewy bodies). | |||||
| Anosmia | 65 (11/17) | 78 (69/89) | 35 (11/31) | 92 (69/75) | 75 (80/106) |
| Anosmic non-smoker | 29 (5/17) | 92 (82/89) | 42 (5/12) | 87 (82/94) | 82 (87/106) |
| Consensus probable DLB | 18 (3/17) | 100 (89/89) | 100 (3/3) | 86 (89/103) | 87 (92/106) |
| With anosmia core feature | 47 (8/17) | 96 (85/89) | 67 (8/12) | 90 (85/94) | 88 (93/106) |
| With anosmic non-smoker | 41 (7/17) | 99 (88/89) | 88 (7/8) | 90 (88/98) | 90 (95/106) |
| Consensus possible DLB | 53 (9/17) | 81 (72/89) | 35 (9/26) | 90 (72/80) | 76 (81/106) |
| Consensus possible DLB or anosmia | 76 (13/17) | 63 (56/89) | 28 (13/46) | 93 (56/60) | 65 (69/106) |
| Consensus possible DLB or anosmic non-smoker | 59 (10/17) | 74 (66/89) | 30 (10/33) | 90 (66/73 | 72 (76/106) |