Study | Eligibility criteria* | MCI inclusion criteria | Exclusion criteria | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age (years) | MMSE score | Other | Functional impairment | Test impairment | Depression | Vascular | ||||||||
*All studies required that the subject was not demented at baseline. | ||||||||||||||
†Scale or test was not used in the Maastricht Memory Clinic. An equivalent scale or test was used if possible as described in the text. | ||||||||||||||
BDRS, Blessed dementia rating scale; CDR, clinical demetia rating scale; Edu, years of education; GDS, geriatric depression scale; HDRS, Hamilton depression rating scale; LM-A, delayed recall score of story A from the logical memory test of the Wechsler memory scale; LM, logical memory test from the Wechsler memory scale–revised; m-HIS, modified Hachinski ischaemic scale; MMSE, mini-mental state examination; NYU, New York University paragraph recall. | ||||||||||||||
Gal-Int-11 | >50 | – | – | CDR 0.5† | NYU <11† | Moderately severe depression | – | |||||||
InDDEx | 55 to 85 | – | – | CDR 0.5† | NYU <9† | HDRS >12; HDRS item 1>1; DSM-IV major depression | m-HIS>4 | |||||||
ADCS-MIS | 55 to 90 | >23 | – | CDR 0.5† | Edu <8: LM-A <3† | HDRS >12 | m-HIS>4 | |||||||
Edu 8–15: LM-A <5† | ||||||||||||||
Edu >15: LM-A <9† | ||||||||||||||
Ampakine | 55 to 80 | >24 | – | CDR 0.5† | Edu <8: LM-A <5† | GDS >6† | m-HIS>4 | |||||||
Edu 8–15: LM-A <8† | ||||||||||||||
Edu >15: LM-A <13† | ||||||||||||||
Piracetam | 50 to 90 | – | Score of at least one point above the lowest possible score on 7 of 8 tests from a cognitive battery† | CDR 0.5† | LM immediate recall <10 or difference immediate and delayed recall LM >5† | HDRS >17† | – | |||||||
Rofecoxib | >65 | >23 | BDRS: score <4 on sum items 1–12 and score on first 8 items all <1 | CDR 0.5† | RAVLT summed immediate recall < 38 | HDRS >12 | m-HIS>4 |