Baseline characteristics of subjects according to different definitions of mild cognitive impairment
| MCI definition in Gal-Int-11 study (n = 77) | MCI definition in InDDEx study (n = 32) | MCI definition in ADCS-MIS study (n = 25) | MCI definition in ampakine study (n = 33) | MCI definition in piracetam study (n = 61) | MCI definition in rofecoxib study (n = 25) | |
|---|---|---|---|---|---|---|
| Values are mean (SD) unless specified otherwise. | ||||||
| *Low: less than 8 years of education; middle: 8 to 15 years of education; high: 16 or more years of education. | ||||||
| †z score indicates the number of standard deviations from the average of a healthy control population.14 A negative z score indicates a score below the average. | ||||||
| AD, Alzheimer’s disease; ADCS-MIS, Alzheimer’s disease cooperative study-memory impairment study; AVLT, auditory verbal learning task Gal-Int-11, galantamine international study 11; GDS, global deterioration scale; HDRS, Hamilton depression rating scale; InDDEx, investigation into delay to diagnosis of Alzheimer’s disease with Exelon; MCI, mild cognitive impairment; m-HIS, modified Hachinski ischaemic scale; MMSE, mini-mental state examination. | ||||||
| Age | 64.2 (8.4) | 66.6 (6.9) | 68.2 (6.5) | 67.8 (7.0) | 64.5 (8.9) | 70.9 (4.2) |
| Male:female (% male) | 47:30 (61) | 20:12 (63) | 17:8 (68) | 21:12 (64) | 35:26 (57) | 18:7 (72) |
| Years of education | 10.2 (3.1) | 10.8 (3.4) | 11.1 (3.7) | 11.0 (3.4) | 10.4 (3.3) | 10.7 (3.2) |
| Education (%)* | ||||||
| Low | 10 (13) | 3 (9) | 3 (12) | 3 (9) | 9 (15) | 3 (12) |
| Middle | 60 (78) | 24 (75) | 17 (68) | 24 (73) | 46 (75) | 19 (76) |
| High | 7 (9) | 5 (16) | 5 (20) | 6 (18) | 6 (10) | 3 (12) |
| GDS score | 2.7 (0.47) | 2.6 (0.50) | 2.7 (0.46) | 2.7 (0.48) | 2.7 (0.44) | 2.8 (0.41) |
| GDS 2 (%) | 25 (33) | 14 (44) | 7 (28) | 11 (33) | 16 (26) | 5 (20) |
| GDS 3 (%) | 52 (67) | 18 (56) | 18 (72) | 22 (67) | 45 (74) | 20 (80) |
| HDRS score | 8.6 (5.1) | 4.7 (3.2) | 5.2 (3.7) | 5.6 (3.6) | 8.6 (5.1) | 7.1 (3.5) |
| m-HIS | 1.4 (1.7) | 1.0 (1.3) | 0.96 (1.3) | 1.0 (1.2) | 1.3 (1.7) | 0.84 (1.1) |
| MMSE score | 27.6 (1.8) | 27.1 (1.7) | 26.7 (1.2) | 27.3 (1.4) | 27.3 (1.8) | 27.4 (1.4) |
| Delayed recall AVLT (z score†) | −1.5 (1.2) | −1.7 (1.4) | −2.2 (1.1) | −2.0 (1.2) | −1.7 (1.2) | −1.5 (1.1) |
| Fluency animals (z score†) | −0.78 (0.83) | −0.96 (0.82) | −1.1 (0.84) | −0.99 (0.82) | −0.85 (0.79) | −0.91 (0.80) |
| Subjects with predementia AD (%) | 33 (43) | 18 (56) | 19 (76) | 23 (70) | 29 (48) | 13 (52) |