Table 3

Diagnosis of sporadic CJD

▸ Awareness of sCJD
▸ A rapidly progressive dementia
▸ Other early neurological features (especially cerebellar or visual)
▸ Myoclonus
▸ Exclusion of other diagnoses (including other forms of CJD)
▸ MRIExclusion of other diagnoses
Findings suggestive of sCJD
▸ EEGPeriodic discharges
▸ CSFExclusion of other diagnoses (e.g. no pleocytosis)
Positive 14-3-3