Differences between sporadic and variant CJD
| sCJD | vCJD | |
|---|---|---|
| Mean age at death | 66 years | 29 years |
| Median duration of illness | 4 months | 14 months |
| Thalamic MRI high signal | Caudate/putamen 60% | Pulvinar 90% |
| EEG | “Typical” 70% | “Typical” 0% |
| Neuropathology | Plaques 10% | Florid plaques 100% |