Results of cerebrospinal fluid and serum sample analysis after admission (as far as we know this is the first time that markers of cell damage and immune reaction have been measured in a patient with acute toscana virus meningoencephalitis)
| Reference range | Day 2 | Day 6 | Day 13 | Day 27 | |||
|---|---|---|---|---|---|---|---|
| CSF, cerebrospinal fluid; EIA, enzyme immunosorbent assay; IFA, immunofluorescence assay; NA, not assessed; WBC, white blood cell. | |||||||
| WBC count (cells/mm3) | 0 to 5 | 265 | 60 | 30 | 16 | ||
| Lactate (mmol/l) | 1.1 to 2.2 | 4.3 | 3.1 | 2.5 | 2.2 | ||
| Glucose (mmol/l) | 2.78 to 4.16 | 7.33 | 6.16 | 4.88 | 4.50 | ||
| Total protein (mg/dl) | 15–45 | 47 | 32 | 25 | 28 | ||
| Oligoclonal banding | Negative | Negative | One band | Negative | Negative | ||
| Tau protein (pg/ml) | <350 | 194 | NA | 191 | 332 | ||
| β2-Microglobulin (mg/l) | <2 | NA | 5 | 3.2 | 3.1 | ||
| Neurone specific enolase (ng/ml) | <12.5 | 8.2 | 7.5 | 5.3 | 7.1 | ||
| S-100 protein (pg/ml) | <2300 | NA | 1030 | NA | 644 | ||
| Anti-TOSV antibodies in CSF | |||||||
| IgG IFA | <1:10 | 1:20 | 1:80 | 1:2560 | 1:5120 | ||
| IgM IFA | <1:10 | <1:10 | <1:10 | <1:10 | <1:10 | ||
| IgG EIA | – | – | + | – | – | ||
| IgM EIA | – | + | + | + | + | ||
| Anti-TOSV antibodies in serum | |||||||
| IgG IFA | <1:10 | 1:640 | 1:2560 | 1:5120 | 1:10240 | ||
| IgM IFA | <1:10 | 1:80 | 1:320 | 1:160 | 1:160 | ||
| IgG EIA | – | + | + | + | + | ||
| IgM EIA | – | + | + | + | + | ||