SPM analysis: regions of hypoperfusion (voxel clusters with significance of patient groups compared with controls) in the combined multiple sclerosis cohort and clinical subgroups of multiple sclerosis.
| Region | All MS | SP | PP | B |
|---|---|---|---|---|
| No regions of hypoperfusion were detected in the relapsing remitting subgroup. | ||||
| MS, multiple sclerosis; SP, secondary progressive; PP, primary progressive; B, benign; GM, grey matter; WM, white matter; R, right; L, left. | ||||
| Percentages of grey and white matter for each subgroup are derived from the total number of clusters in these regions as determined using the Montreal Neurological Institute brain template. | ||||
| Deep grey matter and adjacent white matter | 50% GM; 50% WM | 50% GM; 50% WM | 52% GM; 48% WM | 43% GM; 57% WM |
| R and L thalamus, caudate and extranuclear areas | 2399; p⩽0.001 | 473; p = 0.001 | 2214; p⩽0.001 | 143; p = 0.004 |
| Cortical grey matter and adjacent white matter | 66% GM; 34% W | 56% GM; 44% W | 56% GM; 44% W | 76% GM; 24% W |
| R and L middle frontal and precentral and postcentral gyri and inferior parietal areas | 1450; p⩽0.001 | 1469; p⩽0.001 | 1802; p⩽0.001 | 526; p⩽0.001 |
| R and L superior frontal and medial gyrus | 1049; p⩽0.001 | 614; p⩽0.001 | 4668; p⩽0.001 | NS |
| R and L precuneus and cingulate gyri | 390; p⩽0.001 | NS | 824; p⩽0.001 | NS |
| R and L paracentral lobule | 259; p = 0.001 | NS | NS | NS |
| L superior parietal lobule and subgyral areas | 185; p = 0.007 | NS | 210; p = 0.010 | NS |