Characteristics of patients expressed as medians (interquartile range)
| Feature | Controls | Acute optic neuritis | p Value |
|---|---|---|---|
| MRI, magnetic resonance imaging; NA, not assessed; NfHSM135, phosphorylated neurofilament heavy chain; nitric oxide metabolites; RAPD, relative afferent pupillary deficit; VFD, visual field defect. | |||
| Age (years) | 36 (30–43) | 36 (35–46) | |
| Male/female | 4/10 | 9/5 | <0.05 |
| Eye | N/A | R 8/L 6 | |
| RAPD | N/A | R 8/L 5 | |
| Visual acuity | 1.2 | 0.2 (0.05–0.67) | |
| Colour vision | 17/17 | 0/17 (0/17–7/17) | |
| Disc appearance | Normal | 2 swollen, 12 normal | |
| Time from onset | N/A | 14 days (8–26) | |
| Follow up | N/A | 171 days (25–189) | |
| MRI | N/A | 10 | |
| Plasma NfHSMI35 (ng/ml) | 0.005 (0.0–0.094) | 0.17 (0.07–0.33) | <0.001 |
| Plasma NOx (μM) | 36.2 (31.2–38.6) | 48.1 (40.8–54.2) | <0.01 |
| Plasma citrulline (nmol/ml) | 83.4 (72.1–92.4) | 67.9 (62.5–91.9) | NS |