Allelic association of chromosome 21q22 markers in patients with amyotrophic lateral sclerosis who have the SOD1 R115G mutation
| Frequency | ||||
|---|---|---|---|---|
| Marker* | Allele | R115G patients (n = 4) | Controls (n = 90) | p Value† |
| *Order of markers (centromere to telomere): Yorick - 41 kb - SNP SOD1 intron 1 - 2.9 kb - SNP SOD1 intron 3 - 234 kb - D21S63. †All other alleles (that is, non-7, non-A, non-C, non-4) were combined. | ||||
| Yorick | 7 | 1.0 | 0.21 | <0 0.001 |
| SNP SOD1 intron 1 | A | 1.0 | 0.12 | <0 0.001 |
| SNP SOD1 intron 3 | C | 1.0 | 0.10 | < 0.001 |
| D21S63 | 4 | 1.0 | 0.09 | < 0.001 |