Phenotype frequencies of alleles encoding HLA-DR molecules containing a glutamic acid residue at β171 or β174
| Serological group* | DRB1 allele† | PP-MS (n = 50) | RR/SP-MS (n = 71) | Controls (n = 109) |
|---|---|---|---|---|
| *DR2, DR3, DR7, DR8, and DR10 alleles do not encode HLA-DR molecules containing a glutamic acid residue at β171 or β174 and are therefore not included in the table. | ||||
| †Only alleles carried by patients and/or controls are shown. | ||||
| ‡Significantly decreased in RR/SP-MS compared with PP-MS (odds ratio = 0.22 (0.09 to 0.54); pc = 0.02) and compared with controls (0.27 (0.12 to 0.61); pc = 0.038); p values are corrected for 42 comparisons. | ||||
| MS, multiple sclerosis; PP, primary progressive; RR, relapsing-remitting; SP, secondary progressive. | ||||
| DR1 | 0103 | 2 (4%) | 2 (2.8%) | 4 (3.7%) |
| DR4 | 0402 | 2 (4%) | 1 (1.4%) | 0 (0%) |
| 0403 | 0 (0%) | 0 (0%) | 7 (6.4%) | |
| 0406 | 0 (0%) | 0 (0%) | 1 (0.9%) | |
| 0407 | 4 (8%) | 0 (0%) | 6 (5.5%) | |
| DR5 | 1103 | 0 (0%) | 0 (0%) | 1 (0.9%) |
| DR6 | 1301 | 2 (4%) | 3 (4.2%) | 3 (2.8%) |
| 1302 | 5 (10%) | 2 (2.8%) | 8 (7.3%) | |
| 1401 | 4 (8%) | 1 (1.4%) | 7 (6.4%) | |
| 1404 | 0 (0%) | 0 (0%) | 1 (0.9%) | |
| 1405 | 0 (0%) | 0 (0%) | 1 (0.9%) | |
| 1407 | 0 (0%) | 0 (0%) | 1 (0.9%) | |
| DR9 | 0901 | 1 (2%) | 0 (0%) | 3 (2.8%) |
| Glutamic acid at β71 or β74 of DRB1 | 20 (40%) | 9 (12.7%)‡ | 38 (34.9%) | |
| DR53 | DRB4 (all alleles) | 22 (44%) | 26 (36.6%) | 59 (54.1%) |