Table 1

 Effect of the −219 G/T and coding APOE polymorphisms on amyloid loads and cerebral amyloid angiopathy in the frontal cortex of 114 patients with Alzheimer’s disease

PolymorphismGenotypep Value*p Value†
Values are mean per cent amyloid load and (range) except where specified.
*p Values non-adjusted.
†p Values adjusted for impact of APOE −491 A/T, −219 G/T, and ε4 polymorphism on the general linear model of covariance.
CAA, cerebral amyloid angiopathy.
−219 G/T GG+GT TT
n7836
Plaque Aβn-401.4 (0.3 to 7.3)3.1 (1.2 to 8.4)0.0070.02
Plaque Aβn-428.5 (5.1 to 14.1)10.4 (6.5 to 16.5)NSNS
Total plaque Aβ11.5 (6.9 to 19.3)14.4 (8.7 to 23.9)0.0320.045
n6031
Frontal CAA level (mean (SD))1.9 (0.8)1.7 (0.8)NSNS
−491 A/T TT+AT AA
n2094
Plaque Aβn-401.6 (0.4 to 6.8)1.8 (0.4 to 8.7)NSNS
Plaque Aβn-4210.0 (6.6 to 15.1)9.3 (5.5 to 15.6)NSNS
Total plaque Aβ12.3 (7.8 to 19.5)12.5 (7.3 to 21.2)NSNS
n1576
Frontal CAA level (mean (SD))1.8 (0.6)1.7±0.5NSNS
APOE ε4 ε4+
n4074
Plaque Aβn-400.9 (0.2 to 4.3)2.3 (0.5 to 11.4)0.014NS
Plaque Aβn-429.8 (6.1 to 15.8)9.1 (5.4 to 15.2)NSNS
Total plaque Aβ11.8 (7.5 to 18.7)12.7 (7.3 to 22.2)NSNS
n3259
Frontal CAA level (mean (SD))1.7 (1.9)1.9 (0.8)NSNS