Table 2

 Effect of the −219 G/T polymorphism on amyloid load according to age in the brains of 114 patients with Alzheimer’s disease

GenotypeAge less than median*Age more than median*p Value
GG+GTTTp ValueGG+GTTT
Values are mean per cent amyloid load with (range).
*Age classes were defined by median age at death (72.5 years).
n42163620
Plaque Aβn-402.0 (0.3 to 12.3)3.0 (1.1 to 8.35)NS0.9 (0.2 to 5.5)3.2 (1.2 to 8.9)0.007
Plaque Aβn-429.3 (5.8 to 15.0)9.7 (6.1 to 15.4)NS8.4 (5.2 to 13.6)11.0 (6.9 to 17.5)0.035
Total plaque Aβ12.4 (7.5 to 20.6)13.5 (8.1 to 22.5)NS10.5 (6.4 to 17.4)15.2 (9.1 to 25.2)0.016