Table 2

Quality of Life in Parkinson’s disease

Reference	Class	Target	n	Age, mean (years)	Mean duration of disease (years)	HRQoL tool	Follow up (months)	HRQoL improvements
GPi, globus pallidus; M, medically treated; NA, not available; P, unilateral pallidotomy; PDQ-39SI, Parkinson’s Disease Questionnaire Summary Index; PDQL, Parkinson’s Disease Quality of Life questionnaire; S, STN-DBS; SF-36, Medical Outcomes Study 36-item Short-Form General Health Survey; SIP, Sickness Impact Profile; STN, subthalamic nucleus; v, Spanish version; Vim, thalamus.
*p<0.05.
†Mean score improvement.
Esselink et al²⁰	1b	STN	S = 20	S: 61 (55–66)	S: 12 (9–17)	PDQL	6	Mean total score improvement of
			P = 14	P: 62 (57–68)	P: 11 (9–16)			13 and 18 in P and S, respectively
Lagrange et al²²	2	STN	60	56 (SD 10)	14 (SD 8)	PDQL	12	Total score improved 43%*
Spottke et al²⁵	2	STN	16	56 (SD 8.5)	10.8 (SD 3.9)	SIP	6	Total score improved 58%*
Martinez-Martin et al²³	2	STN	17	60.9 (43–74)	16.4 (7–38)	PDQ-39	6	Total score improved 49%*
Patel et al²⁴	2	STN	16	56 (SD 11)	10 (SD 3.5)	PDQ-39	12	Total score improved 14%*
Just and Ostergaard²¹	2	STN	S = 11	S: 59.8 (51.8–70.9)	S: 14 (7–25)	PDQ-39	3, 6	Mean total score improved 16.1*†
			M = 13	M: 61.4 (53.8–69.2)	M: 16 (10–27)			in the surgically and –0.4*† in the
								medically treated groups
Tröster et al²⁶	2	STN	26	56.6 (SD 11)	9.5 (SD 4.9)	PDQ-39	3	Total score improved from 42.8 to 29.4*†
Lezcano et al²⁷	2	STN	14	63.2 (SD 8.6)	14.3 (SD 5)	PDQ-39	12, 24	Total score improved 62%*
Woods et al²⁹	3	Vim	6	70.83 (SD 8.75)	7.33 (SD 2.66)	PDQ-39	12	PDQ-39SI non-significant improvement
Straits-Troster et al²⁸	3	Vim	7	65.1 (SD 12.0)	8 (SD 3.8)	SIP	3	Total SIP score non-significant improvement
Straits-Troster et al²⁸	3	GPi	9	50.3 (SD 13)	10.3 (SD 4.9)	SIP	3	Total SIP score improved*