Safety and tolerability measures during the time period of each exposure
| Donepezil (n = 21) | Placebo (n = 20) | p value | ||||
|---|---|---|---|---|---|---|
| UPDRS, Unified Parkinson’s Disease Rating Scale (higher worse). AE, adverse event. | ||||||
| Tolerability | 17/21 | 18/20 | 0.41 | |||
| Total UPDRS (mean (SD)) | 63.4 (22.7) | 65.7 (21.3) | 0.44 | |||
| Motor UPDRS (mean (SD)) | 40.3 (13.6) | 40.5 (13.7) | 0.76 | |||
| Any AE | 11 | 9 | 0.64 | |||
| Nausea | 3 | 1 | 0.32 | |||
| Diarrhoea | 1 | 1 | 0.97 | |||
| Psychosis/agitation | 5 | 5 | 0.92 | |||
| Arrhythmia | 1 | 0 | 0.32 | |||